GSK-LSD1 dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407189

CAS#: 1821798-25-7 (2HCl)

Description: GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. GSK-LSD1 inhibits LSD1 with an IC50 of 16 nM and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Lysine specific demethylase 1 (LSD1) is a histone demethylase found in various transcriptional co-repressor complexes. LSD1 is involved in ES cell differentiation, hematopoiesis, and has been described as having a role in Acute Myeloid Leukemia (AML). (

Chemical Structure

GSK-LSD1 dihydrochloride
CAS# 1821798-25-7 (2HCl)

Theoretical Analysis

MedKoo Cat#: 407189
Name: GSK-LSD1 dihydrochloride
CAS#: 1821798-25-7 (2HCl)
Chemical Formula: C14H22Cl2N2
Exact Mass:
Molecular Weight: 289.24
Elemental Analysis: C, 58.14; H, 7.67; Cl, 24.51; N, 9.69

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 Same day
25.0mg USD 250.0 Same day
50.0mg USD 450.0 Same day
100.0mg USD 750.0 Same day
200.0mg USD 1250.0 Same day
500.0mg USD 1950.0 Same day
1.0g USD 2950.0 Same day
2.0g USD 5450.0 Same day
5.0g USD 8650.0 2 weeks
Click to view more sizes and prices
Bulk inquiry

Related CAS #: 2102933-95-7 (rel-2HCl)   1431367-49-5 (rel-HCl)   1431368-48-7 (rel-free base)   1821798-25-7 (2HCl)   1431367-51-9 (HCl)   1431368-50-1 (free base)    

Synonym: GSK-LSD1 dihydrochloride; GSK-LSD1 HCl; GSK-LSD1 2HCl; GSK-LSD1; GSK-LSD-1; GSK-LSD 1;

IUPAC/Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride


InChi Code: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1

SMILES Code: [H]Cl.[H]Cl.C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 289.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.