WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407189
CAS#: 1821798-25-7 (2HCl)
Description: GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. GSK-LSD1 inhibits LSD1 with an IC50 of 16 nM and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Lysine specific demethylase 1 (LSD1) is a histone demethylase found in various transcriptional co-repressor complexes. LSD1 is involved in ES cell differentiation, hematopoiesis, and has been described as having a role in Acute Myeloid Leukemia (AML). (http://www.thesgc.org/chemical-probes/GSK-LSD1)
MedKoo Cat#: 407189
Name: GSK-LSD1 dihydrochloride
CAS#: 1821798-25-7 (2HCl)
Chemical Formula: C14H22Cl2N2
Molecular Weight: 289.24
Elemental Analysis: C, 58.14; H, 7.67; Cl, 24.51; N, 9.69
Related CAS #: 2102933-95-7 (rel-2HCl) 1431367-49-5 (rel-HCl) 1431368-48-7 (rel-free base) 1821798-25-7 (2HCl) 1431367-51-9 (HCl) 1431368-50-1 (free base)
Synonym: GSK-LSD1 dihydrochloride; GSK-LSD1 HCl; GSK-LSD1 2HCl; GSK-LSD1; GSK-LSD-1; GSK-LSD 1;
IUPAC/Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride
InChi Key: PJFZOGMSPBHPNS-WICJZZOFSA-N
InChi Code: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
SMILES Code: [H]Cl.[H]Cl.C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 289.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|