Acetophenazine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317156

CAS#: 2751-68-0

Description: Acetophenazine is discontinued (DEA controlled substance). It is an antipsychotic drug used in the treatment of psychosis. It is also used to treat hallucinations or delusions. It primarily targets the dopamine D2 receptor.


Chemical Structure

img
Acetophenazine
CAS# 2751-68-0

Theoretical Analysis

MedKoo Cat#: 317156
Name: Acetophenazine
CAS#: 2751-68-0
Chemical Formula: C23H29N3O2S
Exact Mass: 411.19805
Molecular Weight: 411.56
Elemental Analysis: C, 67.12; H, 7.10; N, 10.21; O, 7.77; S, 7.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tindal; Acephenazinum; Acetophenazine.

IUPAC/Chemical Name: 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone

InChi Key: WNTYBHLDCKXEOT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3

SMILES Code: CC(C(C=C1N2CCCN3CCN(CCO)CC3)=CC=C1SC4=C2C=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 411.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Bisson WH, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R. Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. Epub 2007 Jul 2. PubMed PMID: 17606915; PubMed Central PMCID: PMC1924583.

2: Danielsson E, Peterson LL, Grundin R, Ogren SO, Bartfai T. Anticholinergic potency of psychoactive drugs in human and rat cerebral cortex and striatum. Life Sci. 1985 Apr 15;36(15):1451-7. PubMed PMID: 2858803.

3: Tam SW, Cook L. Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21. PubMed PMID: 6147851; PubMed Central PMCID: PMC391758.

4: Issa AS, Mahrous MS. Titrimetric determination of some phenothiazine derivatives, with ferricyanide. Talanta. 1984 Apr;31(4):287-8. PubMed PMID: 18963590.

5: Bigelow LB, Weinberger DR, Wyatt RJ. Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study. Am J Psychiatry. 1981 Jan;138(1):81-3. PubMed PMID: 7192495.

6: Bhargava HN. Modification of pharmacological and toxicological effects of acetophenazine, chlorpromazine and thloridazine in morphine-dependent mice. Arch Int Pharmacodyn Ther. 1979 Mar;238(1):165-76. PubMed PMID: 573604.

7: Jones GL, Woodbury DM. Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. J Pharmacol Exp Ther. 1978 Oct;207(1):203-11. PubMed PMID: 702341.

8: Iizuka Hadachi K, Halprin KM, Levine V. Histamine (H2) receptor-adenylate cyclase system in pig skin (epidermis). Biochim Biophys Acta. 1976 Jun 23;437(1):150-7. PubMed PMID: 7311.

9: Hollister LE, Overall JE, Pokorny AD, Shelton J. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8. PubMed PMID: 5100621.

10: Cahan RB. Acetophenazine for office treatment of paranoid symptoms. West Med Med J West. 1967 Mar-Apr;8(3):71-2. PubMed PMID: 6072166.