WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317155

CAS#: 968-81-0

Description: Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.

Chemical Structure

CAS# 968-81-0

Theoretical Analysis

MedKoo Cat#: 317155
Name: Acetohexamide
CAS#: 968-81-0
Chemical Formula: C15H20N2O4S
Exact Mass: 324.11438
Molecular Weight: 324.4
Elemental Analysis: C, 55.54; H, 6.21; N, 8.64; O, 19.73; S, 9.88

Size Price Shipping out time Quantity
100mg USD 190 2 Weeks
500mg USD 550 2 Weeks
1g USD 850 2 Weeks
2g USD 1450 2 Weeks
5g USD 2250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-07. Prices are subject to change without notice.

Acetohexamide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Acetohexamide; Dymelor; Gamadiabet; Acetohexamid; Dimelin; Dimelor

IUPAC/Chemical Name: 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea


InChi Code: InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Aldawsari H, Altaf A, Banjar ZM, Iohara D, Nakabayashi M, Anraku M, Uekama K, Hirayama F. Crystallization of a new polymorph of acetohexamide from 2-hydroxybutyl-β-cyclodextrin solution: form VI with a high aqueous solubility. Int J Pharm. 2013 Sep 10;453(2):315-21. doi: 10.1016/j.ijpharm.2013.06.026. Epub 2013 Jun 21. PubMed PMID: 23796835.

2: Kretschy N, Teichmann M, Kopf S, Atanasov AG, Saiko P, Vonach C, Viola K, Giessrigl B, Huttary N, Raab I, Krieger S, Jäger W, Szekeres T, Nijman SM, Mikulits W, Dirsch VM, Dolznig H, Grusch M, Krupitza G. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8. doi: 10.1038/bjc.2012.580. Epub 2013 Jan 8. PubMed PMID: 23299527; PubMed Central PMCID: PMC3593542.

3: Joseph KS, Anguizola J, Jackson AJ, Hage DS. Chromatographic analysis of acetohexamide binding to glycated human serum albumin. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2775-81. doi: 10.1016/j.jchromb.2010.08.021. Epub 2010 Aug 21. PubMed PMID: 20829128; PubMed Central PMCID: PMC2952882.

4: Tokunaga H, Uchino T. [Studies for analyzing the prohibited ingredients such as acetohexamide in cosmetics]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2005;(123):19-22. Japanese. PubMed PMID: 16541746.

5: Imamura Y, Shimada H. Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase. Biol Pharm Bull. 2005 Jan;28(1):185-7. PubMed PMID: 15635190.

6: Imamura Y, Kaneko M, Takada H, Otagiri M, Shimada H, Akita H. Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec;133(4):587-92. PubMed PMID: 12458186.

7: Shimada H, Yamaguchi S, Murata H, Otagiri M, Imamura Y. Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity. Arch Toxicol. 2002 Feb;76(1):8-12. Epub 2001 Dec 20. PubMed PMID: 11875619.

8: Imamura Y, Sanai K, Seri K, Akita H. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide. Life Sci. 2001 Sep 7;69(16):1947-55. PubMed PMID: 11693275.

9: Imamura Y, Uchida A, Takada H, Otagiri M, Tsuchiya K. [Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals]. Yakugaku Zasshi. 2001 Jan;121(1):85-91. Japanese. PubMed PMID: 11201165.

10: Imamura Y, Koga T, Uriu Y, Otagiri M, Satoh K, Hara A. Catalytic properties for naphthoquinones and partial primary structure of rabbit heart acetohexamide reductase. Biol Pharm Bull. 2000 Feb;23(2):155-8. PubMed PMID: 10706377.