WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317154

CAS#: 13461-01-3 (free)

Description: Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

Chemical Structure

CAS# 13461-01-3 (free)

Theoretical Analysis

MedKoo Cat#: 317154
Name: Aceprometazine
CAS#: 13461-01-3 (free)
Chemical Formula: C19H22N2OS
Exact Mass: 326.14528
Molecular Weight: 326.46
Elemental Analysis: C, 69.90; H, 6.79; N, 8.58; O, 4.90; S, 9.82

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Related CAS #: 13461-01-3 (free)   7455-18-7 (maleate)  

Synonym: Mepronizine; Acepromethazine; Aceprometazine; Aceprometazina; Aceprometazinum; Aceprometazinum; Aceprometazina .

IUPAC/Chemical Name: 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone


InChi Code: InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 326.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zaïem A, Kaabi W, Badri T, Lakhoua G, Sahnoun R, Kastalli S, Daghfous R, Lakhal M, El Aidli S. Meprobamate-induced fixed drug eruption. Curr Drug Saf. 2014;9(2):161-2. PubMed PMID: 24446836.

2: Mounier B, Pons B, Delavenne X, Beyens MN, Rémy C, Zeni F, Mismetti P, Basset T. [Severe meprobamate poisoning: description of 146 cases in a French department]. Therapie. 2012 Mar-Apr;67(2):183-9. doi: 10.2515/therapie/2012019. Epub 2012 Aug 2. French. PubMed PMID: 22850107.

3: Pélissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Léonetti G. Abusive prescription of psychostimulants: a study of two cases. J Forensic Sci. 2006 Mar;51(2):407-10. PubMed PMID: 16566781.

4: Lapostolle F, Finot MA, Adnet F, Borron SW, Baud FJ, Bismuth C. Radiopacity of clomipramine conglomerations and unsuccessful endoscopy: report of 4 cases. J Toxicol Clin Toxicol. 2000;38(5):477-82. PubMed PMID: 10981957.

5: Cherin P, Colvez A, Deville de Periere G, Sereni D. Risk of syncope in the elderly and consumption of drugs: a case-control study. J Clin Epidemiol. 1997 Mar;50(3):313-20. PubMed PMID: 9120531.

6: Mercier J, Dessaigne S, Menguy A, Manez J. Electro-encephalographic study on the action of the combination meprobamate-aceprometazine on various cerebral systems. Arzneimittelforschung. 1974 Feb;24(2):163-6. PubMed PMID: 4406367.


10.0mg / Not available