WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317153

CAS#: 61-00-7 (free base)

Description: Acepromazine is discontinued (DEA controlled substance). It is a phenothiazine derivative that is used in the treatment of psychoses. Acepromazine has a depressant effect on the central nervous system and acts as a dopamine receptor antagonist in the central nervous system, thereby causing sedation, muscular relaxation and a reduction in spontaneous activity. Its fast-acting neuroleptic effect with low toxicity is of particular value in veterinary medicine.

Chemical Structure

CAS# 61-00-7 (free base)

Theoretical Analysis

MedKoo Cat#: 317153
Name: Acepromazine
CAS#: 61-00-7 (free base)
Chemical Formula: C19H22N2OS
Exact Mass: 326.14528
Molecular Weight: 326.46
Elemental Analysis: C, 69.90; H, 6.79; N, 8.58; O, 4.90; S, 9.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 3598-37-6 (maleate)   61-00-7 (free base)    

Synonym: Acetylpromazine; ACEPROMAZINE; Plegicil; Vetranquil; Acetopromazine; Acepromazina; ACP; Ace; Atravet; Acezine 2

IUPAC/Chemical Name: 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone


InChi Code: InChI=1S/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 326.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: López-Sanromán FJ, Gómez Cisneros D, Varela Del Arco M, Santiago Llorente I, Santos González M. The use of low doses of acepromazine as an aid for lameness diagnosis in horses: An accelerometric evaluation. Vet Comp Orthop Traumatol. 2015 Sep 14;28(5):312-7. doi: 10.3415/VCOT-14-11-0177. Epub 2015 Jul 29. PubMed PMID: 26219640.

2: Lopes C, Luna SP, Rosa AC, Quarterone C, Crosignani N, Taylor PM, Pantoja JC, Puoli JN. Antinociceptive effects of methadone combined with detomidine or acepromazine in horses. Equine Vet J. 2015 Jul 14. doi: 10.1111/evj.12483. [Epub ahead of print] PubMed PMID: 26174473.

3: Lorenzutti AM, Martín-Flores M, Litterio NJ, Himelfarb MA, Zarazaga MP. Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine. Vet Anaesth Analg. 2015 Jun 19. doi: 10.1111/vaa.12286. [Epub ahead of print] PubMed PMID: 26095960.

4: Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2015 May 5. doi: 10.1111/vaa.12271. [Epub ahead of print] PubMed PMID: 25943714.

5: Monteiro ER, Coelho K, Bressan TF, Simões CR, Monteiro BS. Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs. Vet Anaesth Analg. 2015 Apr 16. doi: 10.1111/vaa.12265. [Epub ahead of print] PubMed PMID: 25880906.

6: Grasso SC, Ko JC, Weil AB, Paranjape V, Constable PD. Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs. J Am Vet Med Assoc. 2015 Apr 1;246(7):754-64. doi: 10.2460/javma.246.7.754. PubMed PMID: 25794125.

7: Simon BT, Scallan EM, Siracusa C, Henderson A, Sleeper MM, Larenza Menzies MP. Effects of acepromazine or methadone on midazolam-induced behavioral reactions in dogs. Can Vet J. 2014 Sep;55(9):875-85. PubMed PMID: 25183896; PubMed Central PMCID: PMC4137930.

8: Claude AK, Dedeaux A, Chiavaccini L, Hinz S. Effects of maropitant citrate or acepromazine on the incidence of adverse events associated with hydromorphone premedication in dogs. J Vet Intern Med. 2014 Sep-Oct;28(5):1414-7. doi: 10.1111/jvim.12414. Epub 2014 Aug 21. PubMed PMID: 25146756.

9: Lian M, Evans AL, Bertelsen MF, Fahlman Å, Haga HA, Ericsson G, Arnemo JM. Improvement of arterial oxygenation in free-ranging moose (Alces alces) immobilized with etorphine-acepromazine-xylazine. Acta Vet Scand. 2014 Aug 15;56:51. doi: 10.1186/s13028-014-0051-5. PubMed PMID: 25124367; PubMed Central PMCID: PMC4236542.

10: Leite CR, Ascoli FO, de Oliveira J, Brandão FZ. Steep drop in hematocrit of sheep undergoing sedation with acepromazine-diazepam and epidural injections of ketamine, ketamine-morphine or ketamine-xylazine. Vet Anaesth Analg. 2015 Mar;42(2):226-7. doi: 10.1111/vaa.12222. Epub 2014 Aug 12. PubMed PMID: 25112172.