WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407186
Description: PLX7683 is a paradox breaker. Paradox breakers overcame several known mechanisms of resistance to first-generation RAF inhibitors. Dissociating MAPK pathway inhibition from paradoxical activation might yield both improved safety and more durable efficacy than first-generation RAF inhibitors
MedKoo Cat#: 407186
Chemical Formula: C23H19ClF2N4O3S
Exact Mass: 504.08345
Molecular Weight: 504.94
Elemental Analysis: C, 54.71; H, 3.79; Cl, 7.02; F, 7.53; N, 11.10; O, 9.51; S, 6.35
PLX7683 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: PLX7683; PLX-7683; PLX 7683.
IUPAC/Chemical Name: Sulfamide, N'-[4-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-3,5-difluorophenyl]-N-ethyl-N-methyl-
InChi Key: LLAFAUCUKNMECC-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28)
SMILES Code: O=S(NC1=CC(F)=C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)C(F)=C1)(N(CC)C)=O
The following data is based on the product molecular weight 504.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing
T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S,
Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters
J, Tsai J, West BL, Visor G, Rezaei H, Lin PS, Nolop K, Ibrahim PN, Hirth P,
Bollag G. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature.
2015 Oct 22;526(7574):583-6. doi: 10.1038/nature14982. Epub 2015 Oct 14. PubMed