WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407186
CAS#: 1652573-86-8
Description: PLX7683 is a paradox breaker. Paradox breakers overcame several known mechanisms of resistance to first-generation RAF inhibitors. Dissociating MAPK pathway inhibition from paradoxical activation might yield both improved safety and more durable efficacy than first-generation RAF inhibitors
MedKoo Cat#: 407186
Name: PLX7683
CAS#: 1652573-86-8
Chemical Formula: C23H19ClF2N4O3S
Exact Mass: 504.08345
Molecular Weight: 504.94
Elemental Analysis: C, 54.71; H, 3.79; Cl, 7.02; F, 7.53; N, 11.10; O, 9.51; S, 6.35
Synonym: PLX7683; PLX-7683; PLX 7683.
IUPAC/Chemical Name: Sulfamide, N'-[4-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-3,5-difluorophenyl]-N-ethyl-N-methyl-
InChi Key: LLAFAUCUKNMECC-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19ClF2N4O3S/c1-3-30(2)34(32,33)29-16-9-19(25)21(20(26)10-16)22(31)18-12-28-23-17(18)8-14(11-27-23)13-4-6-15(24)7-5-13/h4-12,29H,3H2,1-2H3,(H,27,28)
SMILES Code: O=S(NC1=CC(F)=C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)C(F)=C1)(N(CC)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 504.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing
T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S,
Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters
J, Tsai J, West BL, Visor G, Rezaei H, Lin PS, Nolop K, Ibrahim PN, Hirth P,
Bollag G. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature.
2015 Oct 22;526(7574):583-6. doi: 10.1038/nature14982. Epub 2015 Oct 14. PubMed
PMID: 26466569.
