WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522465

CAS#: 1440209-96-0

Description: BRD73954 is a small molecule inhibitor that potently inhibits HDAC6 and HDAC8. It inhibits HDAC6, a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility. It is also an inhibitor of HDAC8, a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.

Chemical Structure

CAS# 1440209-96-0

Theoretical Analysis

MedKoo Cat#: 522465
Name: BRD73954
CAS#: 1440209-96-0
Chemical Formula: C16H16N2O3
Exact Mass: 284.11609
Molecular Weight: 284.32
Elemental Analysis: C, 67.59; H, 5.67; N, 9.85; O, 16.88

Price and Availability

Size Price Availability Quantity
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1450.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3850.0 2 Weeks
5.0g USD 6950.0 2 Weeks
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Synonym: BRD73954; BRD-73954; BRD 73954.

IUPAC/Chemical Name: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide


InChi Code: InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 284.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, Weïwer M, Zhang YL, Holson EB. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. doi: 10.1021/jm400390r. Epub 2013 May 29. PubMed PMID: 23672185.

(Last update: 4/20/2016).


100.0mg / USD 450.0