PF-06442609
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MedKoo CAT#: 522464

CAS#: 1402002-76-9

Description: PF-06442609 is a potent, metabolic stable γ-secretase modulators (GSMs) for Alzheimer's disease (AD). PF-06442609 displayed a favorable rodent pharmacokinetic profile, and robust reductions of brain Aβ42 and Aβ40 were observed in a guinea pig time-course experiment. F-06442609 is suitable for rodent model of AD.


Chemical Structure

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PF-06442609
CAS# 1402002-76-9

Theoretical Analysis

MedKoo Cat#: 522464
Name: PF-06442609
CAS#: 1402002-76-9
Chemical Formula: C24H24F4N4O3
Exact Mass: 492.17845
Molecular Weight: 492.47
Elemental Analysis: C, 58.53; H, 4.91; F, 15.43; N, 11.38; O, 9.75

Price and Availability

Size Price Availability Quantity
5.0mg USD 240.0 2 Weeks
25.0mg USD 600.0 2 Weeks
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Synonym: PF-06442609; PF 06442609; PF06442609; PF-6442609; PF 6442609; PF6442609.

IUPAC/Chemical Name: 2-((S)-1-(4-fluoro-2-((R)-1,1,1-trifluoropropan-2-yl)phenoxy)propan-2-yl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

InChi Key: XZFBQMFLEPCQCW-JKSUJKDBSA-N

InChi Code: InChI=1S/C24H24F4N4O3/c1-14-11-30(13-29-14)19-5-6-20-23(34)31(8-9-32(20)22(19)33)15(2)12-35-21-7-4-17(25)10-18(21)16(3)24(26,27)28/h4-7,10-11,13,15-16H,8-9,12H2,1-3H3/t15-,16+/m0/s1

SMILES Code: O=C1C(N2CCN1[C@@H](C)COC3=CC=C(F)C=C3[C@@H](C)C(F)(F)F)=CC=C(N4C=C(C)N=C4)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 492.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pettersson M, Johnson DS, Humphrey JM, Butler TW, Am Ende CW, Fish BA, Green
ME, Kauffman GW, Mullins PB, O'Donnell CJ, Stepan AF, Stiff CM, Subramanyam C,
Tran TP, Vetelino BC, Yang E, Xie L, Bales KR, Pustilnik LR, Steyn SJ, Wood KM,
Verhoest PR. Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align
Potency, MDR Efflux Ratio, and Metabolic Stability. ACS Med Chem Lett. 2015 Apr
3;6(5):596-601. doi: 10.1021/acsmedchemlett.5b00070. eCollection 2015 May 14.
PubMed PMID: 26005540; PubMed Central PMCID: PMC4434474.