EPZ020411 HCl
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MedKoo CAT#: 407182

CAS#: 2095432-47-4 (2HCl)

Description: EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. PRMT6 overexpression has been reported in several cancer types suggesting that inhibition of PRMT6 activity may have therapeutic utility. Identification of EPZ020411 provides the field with the first small molecule tool compound for target validation studies. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies.


Chemical Structure

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EPZ020411 HCl
CAS# 2095432-47-4 (2HCl)

Theoretical Analysis

MedKoo Cat#: 407182
Name: EPZ020411 HCl
CAS#: 2095432-47-4 (2HCl)
Chemical Formula: C25H40Cl2N4O3
Exact Mass: 442.29439
Molecular Weight: 515.52
Elemental Analysis: C, 58.25; H, 7.82; Cl, 13.75; N, 10.87; O, 9.31

Price and Availability

Size Price Availability Quantity
25.0mg USD 350.0 2 weeks
50.0mg USD 650.0 2 weeks
100.0mg USD 1150.0 2 weeks
200.0mg USD 1950.0 2 weeks
500.0mg USD 2650.0 2 weeks
1.0g USD 3650.0 2 weeks
2.0g USD 5850.0 2 weeks
5.0g USD 8950.0 2 weeks
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Related CAS #: 2095432-47-4 (2HCl)   1700663-41-7 (free base)   2070015-25-5 (HCl)    

Synonym: EPZ020411; EPZ-020411; EPZ 020411; EPZ020411 HCl; EPZ020411 hydrochloride

IUPAC/Chemical Name: N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine dihydrochloride

InChi Key: QCHZLIPYCYHFLI-PZPNUJOOSA-N

InChi Code: InChI=1S/C25H38N4O3.2ClH/c1-26-10-11-29(2)18-21-17-27-28-25(21)20-3-5-22(6-4-20)32-24-15-23(16-24)31-14-9-19-7-12-30-13-8-19;;/h3-6,17,19,23-24,26H,7-16,18H2,1-2H3,(H,27,28);2*1H/t23-,24-;;

SMILES Code: CNCCN(C)CC1=CNN=C1C2=CC=C(O[C@H]3C[C@H](OCCC4CCOCC4)C3)C=C2.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 515.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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