WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407179
CAS#: 42521-82-4
Description: IPA-3 is a potent and selective PAK1 inhibitor. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. IPA-3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA-3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF-κB. IPA-3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse xenograft assay demonstrated that IPA-3 treatment significantly reduced the tumor growth rate and decreased tumor volume, indicating that IPA-3 can suppress the in vivo tumor growth of HCC cells. Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior, suggesting that PAK1 is a potential therapeutic target in HCC.
MedKoo Cat#: 407179
Name: IPA-3
CAS#: 42521-82-4
Chemical Formula: C20H14O2S2
Exact Mass: 350.04352
Molecular Weight: 350.45
Elemental Analysis: C, 68.55; H, 4.03; O, 9.13; S, 18.30
Synonym: IPA-3; IPA 3; IPA3.
IUPAC/Chemical Name: 1,1'-disulfanediylbis(naphthalen-2-ol)
InChi Key: RFAXLXKIAKIUDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
SMILES Code: OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 350.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated
kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in
mice. Brain Res. 2014 Oct 17;1585:13-22. doi: 10.1016/j.brainres.2014.08.026.
Epub 2014 Aug 20. PubMed PMID: 25148711.
2: Kuželová K, Grebeňová D, Holoubek A, Röselová P, Obr A. Group I PAK inhibitor
IPA-3 induces cell death and affects cell adhesivity to fibronectin in human
hematopoietic cells. PLoS One. 2014 Mar 24;9(3):e92560. doi:
10.1371/journal.pone.0092560. eCollection 2014. PubMed PMID: 24664099; PubMed
Central PMCID: PMC3963893.
3: Wong LL, Lam IP, Wong TY, Lai WL, Liu HF, Yeung LL, Ching YP. IPA-3 inhibits
the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. PLoS
One. 2013 Jul 19;8(7):e68843. doi: 10.1371/journal.pone.0068843. Print 2013.
PubMed PMID: 23894351; PubMed Central PMCID: PMC3716906.
