VU0483605
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522454

CAS#: 1623101-11-0

Description: VU0483605 is a potent and selective positive allosteric modulator (PAM) of mGluR1, displaying EC50 values of 0.39 and 0.36 μM at human and rat receptors, respectively, and no activity as a mGlu4 PAM (EC50 >10 μM).


Chemical Structure

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VU0483605
CAS# 1623101-11-0

Theoretical Analysis

MedKoo Cat#: 522454
Name: VU0483605
CAS#: 1623101-11-0
Chemical Formula: C20H10Cl3N3O3
Exact Mass: 444.97877
Molecular Weight: 446.67
Elemental Analysis: C, 53.78; H, 2.26; Cl, 23.81; N, 9.41; O, 10.75

Price and Availability

Size Price Availability Quantity
5.0mg USD 225.0 2 Weeks
10.0mg USD 365.0 2 Weeks
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Synonym: VU0483605, VU-0483605, VU 048360

IUPAC/Chemical Name: 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide

InChi Key: HJQXPBKPTGWZCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)

SMILES Code: O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 446.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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