SLP120701 HCl

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MedKoo CAT#: 407178

CAS#: 1449768-46-0 (HCl)

Description: SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

Chemical Structure

SLP120701 HCl
CAS# 1449768-46-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 407178
Name: SLP120701 HCl
CAS#: 1449768-46-0 (HCl)
Chemical Formula: C20H30ClN5O
Exact Mass:
Molecular Weight: 391.94
Elemental Analysis: C, 61.29; H, 7.72; Cl, 9.04; N, 17.87; O, 4.08

Size Price Shipping out time Quantity
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Pricing updated 2021-03-02. Prices are subject to change without notice.

SLP120701 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Related CAS #: 1449768-46-0 (HCl)   1449765-80-3 (free base)    

Synonym: SLP120701; SLP-120701; SLP120701.

IUPAC/Chemical Name: (S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboximidamide hydrochloride


InChi Code: InChI=1S/C20H29N5O.ClH/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-14-25(17)20(21)22;/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22);1H/t17-;/m0./s1


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y,
Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic
tail region of sphingosine kinase 2 inhibitors. Bioorg Med Chem Lett. 2015 Nov
1;25(21):4956-60. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. PubMed PMID:
25862200; PubMed Central PMCID: PMC4580500.

Additional Information

Related CAS#
1449768-46-0 ( SLP120701 HCl salt);
1449765-80-3 ( SLP120701 free base)