WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407178
CAS#: 1449768-46-0 (HCl)
Description: SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
MedKoo Cat#: 407178
Name: SLP120701 HCl
CAS#: 1449768-46-0 (HCl)
Chemical Formula: C20H30ClN5O
Molecular Weight: 391.94
Elemental Analysis: C, 61.29; H, 7.72; Cl, 9.04; N, 17.87; O, 4.08
SLP120701 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Related CAS #: 1449768-46-0 (HCl) 1449765-80-3 (free base)
Synonym: SLP120701; SLP-120701; SLP120701.
IUPAC/Chemical Name: (S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboximidamide hydrochloride
InChi Key: SCIZSGHQFGJAFK-LMOVPXPDSA-N
InChi Code: InChI=1S/C20H29N5O.ClH/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-14-25(17)20(21)22;/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22);1H/t17-;/m0./s1
SMILES Code: N=C(N1[C@H](C2=NC(C3=CC=C(CCCCCCCC)C=C3)=NO2)CC1)N.[H]Cl
The following data is based on the product molecular weight 391.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y,
Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic
tail region of sphingosine kinase 2 inhibitors. Bioorg Med Chem Lett. 2015 Nov
1;25(21):4956-60. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. PubMed PMID:
25862200; PubMed Central PMCID: PMC4580500.
1449768-46-0 ( SLP120701 HCl salt);
1449765-80-3 ( SLP120701 free base)