SLP120701 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407178

CAS#: 1449768-46-0 (HCl)

Description: SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.


Chemical Structure

img
SLP120701 HCl
CAS# 1449768-46-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 407178
Name: SLP120701 HCl
CAS#: 1449768-46-0 (HCl)
Chemical Formula: C20H30ClN5O
Exact Mass:
Molecular Weight: 391.94
Elemental Analysis: C, 61.29; H, 7.72; Cl, 9.04; N, 17.87; O, 4.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1449768-46-0 (HCl)   1449765-80-3 (free base)    

Synonym: SLP120701; SLP-120701; SLP120701.

IUPAC/Chemical Name: (S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboximidamide hydrochloride

InChi Key: SCIZSGHQFGJAFK-LMOVPXPDSA-N

InChi Code: InChI=1S/C20H29N5O.ClH/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-23-19(26-24-18)17-13-14-25(17)20(21)22;/h9-12,17H,2-8,13-14H2,1H3,(H3,21,22);1H/t17-;/m0./s1

SMILES Code: N=C(N1[C@H](C2=NC(C3=CC=C(CCCCCCCC)C=C3)=NO2)CC1)N.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 391.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y,
Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic
tail region of sphingosine kinase 2 inhibitors. Bioorg Med Chem Lett. 2015 Nov
1;25(21):4956-60. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. PubMed PMID:
25862200; PubMed Central PMCID: PMC4580500.



Additional Information

Related CAS#
1449768-46-0 ( SLP120701 HCl salt);
1449765-80-3 ( SLP120701 free base)