WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522448
CAS#: 1354712-92-7
Description: PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.
MedKoo Cat#: 522448
Name: PF05020182
CAS#: 1354712-92-7
Chemical Formula: C18H30N4O4
Exact Mass: 366.22671
Molecular Weight: 366.46
Elemental Analysis: C, 59.00; H, 8.25; N, 15.29; O, 17.46
Synonym: PF05020182; PF-05020182; PF 05020182; PF5020182; PF-5020182; PF 5020182.
IUPAC/Chemical Name: N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-butanamide
InChi Key: XHJMCIALHJMEBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23)
SMILES Code: CC(C)(C)CC(NC1=C(OC)N=C(N2CCC(OC)CC2)N=C1OC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 366.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Davoren JE, Claffey MM, Snow SL, Reese MR, Arora G, Butler CR, Boscoe BP,
Chenard L, DeNinno SL, Drozda SE, Duplantier AJ, Moine L, Rogers BN, Rong S,
Schuyten K, Wright AS, Zhang L, Serpa KA, Weber ML, Stolyar P, Whisman TL, Baker
K, Tse K, Clark AJ, Rong H, Mather RJ, Lowe JA 3rd. Discovery of a novel Kv7
channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov
1;25(21):4941-4. doi: 10.1016/j.bmcl.2015.04.074. Epub 2015 May 1. PubMed PMID:
25987375.
