WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522448
CAS#: 1354712-92-7
Description: PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.
MedKoo Cat#: 522448
Name: PF05020182
CAS#: 1354712-92-7
Chemical Formula: C18H30N4O4
Exact Mass: 366.22671
Molecular Weight: 366.46
Elemental Analysis: C, 59.00; H, 8.25; N, 15.29; O, 17.46
PF05020182, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: PF05020182; PF-05020182; PF 05020182; PF5020182; PF-5020182; PF 5020182.
IUPAC/Chemical Name: N-[4,6-Dimethoxy-2-(4-methoxy-1-piperidinyl)-5-pyrimidinyl]-3,3-dimethyl-butanamide
InChi Key: XHJMCIALHJMEBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23)
SMILES Code: CC(C)(C)CC(NC1=C(OC)N=C(N2CCC(OC)CC2)N=C1OC)=O
The following data is based on the product molecular weight 366.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Davoren JE, Claffey MM, Snow SL, Reese MR, Arora G, Butler CR, Boscoe BP,
Chenard L, DeNinno SL, Drozda SE, Duplantier AJ, Moine L, Rogers BN, Rong S,
Schuyten K, Wright AS, Zhang L, Serpa KA, Weber ML, Stolyar P, Whisman TL, Baker
K, Tse K, Clark AJ, Rong H, Mather RJ, Lowe JA 3rd. Discovery of a novel Kv7
channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov
1;25(21):4941-4. doi: 10.1016/j.bmcl.2015.04.074. Epub 2015 May 1. PubMed PMID:
25987375.
