BAM15
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522443

CAS#: 210302-17-3

Description: BAM15 is a potent and selective mitochondrial uncoupler or protonophore. Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such as obesity, Parkinson’s disease, and aging.


Chemical Structure

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BAM15
CAS# 210302-17-3

Theoretical Analysis

MedKoo Cat#: 522443
Name: BAM15
CAS#: 210302-17-3
Chemical Formula: C16H10F2N6O
Exact Mass: 340.08842
Molecular Weight: 340.29
Elemental Analysis: C, 56.47; H, 2.96; F, 11.17; N, 24.70; O, 4.70

Size Price Shipping out time Quantity
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2450 2 Weeks
2g USD 4250 2 Weeks
5g USD 6850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

BAM15, , purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: BAM15; BAM-15; BAM 15.

IUPAC/Chemical Name: N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

InChi Key: OEGJBRZAJRPPHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)

SMILES Code: FC1=CC=CC=C1NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Shukla S, Lee JS, Park HK, Yoo JA, Hong SY, Kim JK, Kim M. Effect of Novel
Starter Culture on Reduction of Biogenic Amines, Quality Improvement, and Sensory
Properties of Doenjang, a Traditional Korean Soybean Fermented Sauce Variety. J
Food Sci. 2015 Aug;80(8):M1794-803. doi: 10.1111/1750-3841.12942. Epub 2015 Jul
3. PubMed PMID: 26147854.

2: Kenwood BM, Calderone JA, Taddeo EP, Hoehn KL, Santos WL. Structure-activity
relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg Med
Chem Lett. 2015 Nov 1;25(21):4858-61. doi: 10.1016/j.bmcl.2015.06.040. Epub 2015
Jun 16. PubMed PMID: 26119501.

3: Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA,
Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L,
Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S,
Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel
mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab.
2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.
PubMed PMID: 24634817; PubMed Central PMCID: PMC3953706.

4: Kunapuli P, Lee S, Zheng W, Alberts M, Kornienko O, Mull R, Kreamer A, Hwang
JI, Simon MI, Strulovici B. Identification of small molecule antagonists of the
human mas-related gene-X1 receptor. Anal Biochem. 2006 Apr 1;351(1):50-61. Epub
2006 Feb 3. PubMed PMID: 16510108.