BAM15
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522443

CAS#: 210302-17-3

Description: BAM15 is a potent and selective mitochondrial uncoupler or protonophore. Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such as obesity, Parkinson’s disease, and aging.


Chemical Structure

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BAM15
CAS# 210302-17-3

Theoretical Analysis

MedKoo Cat#: 522443
Name: BAM15
CAS#: 210302-17-3
Chemical Formula: C16H10F2N6O
Exact Mass: 340.08842
Molecular Weight: 340.29
Elemental Analysis: C, 56.47; H, 2.96; F, 11.17; N, 24.70; O, 4.70

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 850.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 4250.0 2 Weeks
5.0g USD 6850.0 2 Weeks
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Synonym: BAM15; BAM-15; BAM 15.

IUPAC/Chemical Name: N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

InChi Key: OEGJBRZAJRPPHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)

SMILES Code: FC1=CC=CC=C1NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 340.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shukla S, Lee JS, Park HK, Yoo JA, Hong SY, Kim JK, Kim M. Effect of Novel
Starter Culture on Reduction of Biogenic Amines, Quality Improvement, and Sensory
Properties of Doenjang, a Traditional Korean Soybean Fermented Sauce Variety. J
Food Sci. 2015 Aug;80(8):M1794-803. doi: 10.1111/1750-3841.12942. Epub 2015 Jul
3. PubMed PMID: 26147854.

2: Kenwood BM, Calderone JA, Taddeo EP, Hoehn KL, Santos WL. Structure-activity
relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg Med
Chem Lett. 2015 Nov 1;25(21):4858-61. doi: 10.1016/j.bmcl.2015.06.040. Epub 2015
Jun 16. PubMed PMID: 26119501.

3: Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA,
Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L,
Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S,
Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel
mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab.
2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.
PubMed PMID: 24634817; PubMed Central PMCID: PMC3953706.

4: Kunapuli P, Lee S, Zheng W, Alberts M, Kornienko O, Mull R, Kreamer A, Hwang
JI, Simon MI, Strulovici B. Identification of small molecule antagonists of the
human mas-related gene-X1 receptor. Anal Biochem. 2006 Apr 1;351(1):50-61. Epub
2006 Feb 3. PubMed PMID: 16510108.

BAM15

50.0mg / USD 250.0