WY-14643
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522441

CAS#: 50892-23-4

Description: WY-14643, also known as pirinixic acid, is a selective PPARα agonist. WY-14643 negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.


Chemical Structure

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WY-14643
CAS# 50892-23-4

Theoretical Analysis

MedKoo Cat#: 522441
Name: WY-14643
CAS#: 50892-23-4
Chemical Formula: C14H14ClN3O2S
Exact Mass: 323.04953
Molecular Weight: 323.8
Elemental Analysis: C, 51.93; H, 4.36; Cl, 10.95; N, 12.98; O, 9.88; S, 9.90

Price and Availability

Size Price Availability Quantity
10.0mg USD 110.0 2 Weeks
25.0mg USD 150.0 2 Weeks
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1250.0 2 Weeks
1.0g USD 1950.0 2 Weeks
2.0g USD 2950.0 2 Weeks
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Synonym: WY-14643; WY 14643; WY14643; Pirinixic Acid

IUPAC/Chemical Name: [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid

InChi Key: SZRPDCCEHVWOJX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

SMILES Code: O=C(O)CSC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1

Appearance: White to off-white crystalline powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 323.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Merk D, Zettl M, Steinhilber D, Werz O, Schubert-Zsilavecz M. Pirinixic acids: flexible fatty acid mimetics with various biological activities. Future Med Chem. 2015 Aug;7(12):1597-616. doi: 10.4155/fmc.15.87. Epub 2015 Aug 27. PubMed PMID: 26313377.

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3: Revuelta-López E, Cal R, Julve J, Rull A, Martínez-Bujidos M, Perez-Cuellar M, Ordoñez-Llanos J, Badimon L, Sanchez-Quesada JL, Llorente-Cortés V. Hypoxia worsens the impact of intracellular triglyceride accumulation promoted by electronegative low-density lipoprotein in cardiomyocytes by impairing perilipin 5 upregulation. Int J Biochem Cell Biol. 2015 Aug;65:257-67. doi: 10.1016/j.biocel.2015.06.014. Epub 2015 Jun 19. PubMed PMID: 26096040.

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5: Du WW, Liu F, Shan SW, Ma XC, Gupta S, Jin T, Spaner D, Krylov SN, Zhang Y, Ling W, Yang BB. Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. Mol Ther. 2015 Jul;23(7):1222-33. doi: 10.1038/mt.2015.64. Epub 2015 Apr 21. PubMed PMID: 25896250.

6: Planchais J, Boutant M, Fauveau V, Qing LD, Sabra-Makke L, Bossard P, Vasseur-Cognet M, Pégorier JP. The role of chicken ovalbumin upstream promoter transcription factor II in the regulation of hepatic fatty acid oxidation and gluconeogenesis in newborn mice. Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E868-78. doi: 10.1152/ajpendo.00433.2014. Epub 2015 Mar 17. PubMed PMID: 25783893.

7: Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circ Cardiovasc Genet. 2015 Jun;8(3):427-36. doi: 10.1161/CIRCGENETICS.114.000918. Epub 2015 Mar 10. PubMed PMID: 25759434.

8: Barbosa-da-Silva S, Souza-Mello V, Magliano DC, Marinho Tde S, Aguila MB, Mandarim-de-Lacerda CA. Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice. Life Sci. 2015 Apr 15;127:73-81. doi: 10.1016/j.lfs.2015.02.003. Epub 2015 Mar 4. PubMed PMID: 25748419.

9: Read SA, Tay ES, Shahidi M, McLauchlan J, George J, Douglas MW. The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist. J Interferon Cytokine Res. 2015 Jun;35(6):488-97. doi: 10.1089/jir.2014.0209. Epub 2015 Mar 3. PubMed PMID: 25734487; PubMed Central PMCID: PMC4490708.

10: Haffar T, Bérubé-Simard FA, Bousette N. Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs. Biochem Biophys Res Commun. 2015 Mar 27;459(1):54-9. doi: 10.1016/j.bbrc.2015.02.062. Epub 2015 Feb 21. PubMed PMID: 25712520.

11: Larsen MC, Bushkofsky JR, Gorman T, Adhami V, Mukhtar H, Wang S, Reeder SB, Sheibani N, Jefcoate CR. Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis. Arch Biochem Biophys. 2015 Apr 1;571:21-39. doi: 10.1016/j.abb.2015.02.010. Epub 2015 Feb 20. PubMed PMID: 25703193; PubMed Central PMCID: PMC4387869.

12: Kang HS, Kim MY, Kim SJ, Lee JH, Kim YD, Seo YK, Bae JH, Oh GT, Song DK, Ahn YH, Im SS. Regulation of IGFBP-2 expression during fasting. Biochem J. 2015 May 1;467(3):453-60. doi: 10.1042/BJ20141248. PubMed PMID: 25695641; PubMed Central PMCID: PMC4403943.

13: Penas F, Mirkin GA, Vera M, Cevey Á, González CD, Gómez MI, Sales ME, Goren NB. Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. Biochim Biophys Acta. 2015 May;1852(5):893-904. doi: 10.1016/j.bbadis.2014.12.019. Epub 2014 Dec 31. PubMed PMID: 25557389.

14: Ericsson A, Turner N, Hansson GI, Wallenius K, Oakes ND. Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat. PLoS One. 2014 Dec 8;9(12):e113328. doi: 10.1371/journal.pone.0113328. eCollection 2014. PubMed PMID: 25486018; PubMed Central PMCID: PMC4259322.

15: Lebeck J, Cheema MU, Skowronski MT, Nielsen S, Praetorius J. Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G198-205. doi: 10.1152/ajpgi.00407.2013. Epub 2014 Dec 4. PubMed PMID: 25477377.

16: Pellowska M, Stein C, Pohland M, Merk D, Klein J, Eckert GP, Schubert-Zsilavecz M, Wurglics M. Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity. J Pharm Biomed Anal. 2015 Jan;102:417-24. doi: 10.1016/j.jpba.2014.10.001. Epub 2014 Oct 13. PubMed PMID: 25459941.

17: Watkins AM, Wood CR, Lin MT, Abbott BD. The effects of perfluorinated chemicals on adipocyte differentiation in vitro. Mol Cell Endocrinol. 2015 Jan 15;400:90-101. doi: 10.1016/j.mce.2014.10.020. Epub 2014 Nov 5. PubMed PMID: 25448844.

18: Kossler N, Matheis KA, Ostenfeldt N, Bach Toft D, Dhalluin S, Deschl U, Kalkuhl A. Identification of specific mRNA signatures as fingerprints for carcinogenesis in mice induced by genotoxic and nongenotoxic hepatocarcinogens. Toxicol Sci. 2015 Feb;143(2):277-95. doi: 10.1093/toxsci/kfu248. Epub 2014 Nov 18. PubMed PMID: 25410580.

19: Kurzynska A, Bogacki M, Chojnowska K, Bogacka I. Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy. J Physiol Pharmacol. 2014 Oct;65(5):709-17. PubMed PMID: 25371531.

20: Mussbacher M, Stessel H, Wölkart G, Haemmerle G, Zechner R, Mayer B, Schrammel A. Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. J Mol Cell Cardiol. 2014 Dec;77:11-9. doi: 10.1016/j.yjmcc.2014.09.028. Epub 2014 Oct 5. PubMed PMID: 25285770; PubMed Central PMCID: PMC4263609.

WY-14643

10.0mg / USD 110.0