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UPF-1069
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407176

CAS#: 1048371-03-4

Description: UPF-1069 is a selective and potent PARP2 inhibitor. UPF-1069 induces apoptosis. UPF-1069 shows neuroprotective and anti-ischemic effects in vivo.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 110 2 Weeks
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1250 2 Weeks
1g USD 1950 2 Weeks
2g USD 2950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-31. Prices are subject to change without notice.

UPF-1069, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407176
Name: UPF-1069
CAS#: 1048371-03-4
Chemical Formula: C17H13NO3
Exact Mass: 279.08954
Molecular Weight: 279.29
Elemental Analysis: C, 73.11; H, 4.69; N, 5.02; O, 17.19


Synonym: UPF-1069, UPF1069, UPF 1069

IUPAC/Chemical Name: 5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one

InChi Key: JJWMRRNGWSITSQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)

SMILES Code: O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE. Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci. 2012 Jul;36(1):1993-2005. doi: 10.1111/j.1460-9568.2012.08116.x. Epub 2012 May 28. PubMed PMID: 22639866.

2: Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. PubMed PMID: 19422384; PubMed Central PMCID: PMC2721269.