WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407176
CAS#: 1048371-03-4
Description: UPF-1069 is a selective and potent PARP2 inhibitor. UPF-1069 induces apoptosis. UPF-1069 shows neuroprotective and anti-ischemic effects in vivo.
MedKoo Cat#: 407176
Name: UPF-1069
CAS#: 1048371-03-4
Chemical Formula: C17H13NO3
Exact Mass: 279.08954
Molecular Weight: 279.29
Elemental Analysis: C, 73.11; H, 4.69; N, 5.02; O, 17.19
Synonym: UPF-1069, UPF1069, UPF 1069
IUPAC/Chemical Name: 5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one
InChi Key: JJWMRRNGWSITSQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20)
SMILES Code: O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O
1: Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE. Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci. 2012 Jul;36(1):1993-2005. doi: 10.1111/j.1460-9568.2012.08116.x. Epub 2012 May 28. PubMed PMID: 22639866.
2: Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. PubMed PMID: 19422384; PubMed Central PMCID: PMC2721269.