OAC1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407175

CAS#: 300586-90-7

Description: OAC1 is an Oct-4 activator, octamer-binding transcription factor 4 (Oct4)-activating compound, that enhances the iPSC reprogramming efficiency and accelerated the reprogramming process by 20-fold. OAC-1 also upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1.


Chemical Structure

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OAC1
CAS# 300586-90-7

Theoretical Analysis

MedKoo Cat#: 407175
Name: OAC1
CAS#: 300586-90-7
Chemical Formula: C14H11N3O
Exact Mass: 237.09021
Molecular Weight: 237.26
Elemental Analysis: C, 70.87; H, 4.67; N, 17.71; O, 6.74

Size Price Shipping out time Quantity
10mg USD 110 2 Weeks
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1250 2 Weeks
1g USD 1950 2 Weeks
2g USD 2950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

OAC1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: OAC 1; OAC1; OAC-1

IUPAC/Chemical Name: N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide

InChi Key: HWJRIFZDXJKJJN-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)

SMILES Code: O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 237.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Huang X, Lee MR, Cooper S, Hangoc G, Hong KS, Chung HM, Broxmeyer HE. Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. Leukemia. 2015 Jul 23. doi: 10.1038/leu.2015.189. [Epub ahead of print] PubMed PMID: 26202933.

2: Tsang F, James C, Kato M, Myers V, Ilyas I, Tsang M, Lin SJ. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae. J Biol Chem. 2015 May 15;290(20):12753-64. doi: 10.1074/jbc.M115.644534. Epub 2015 Mar 30. PubMed PMID: 25825491; PubMed Central PMCID: PMC4432292.

3: Li W, Tian E, Chen ZX, Sun G, Ye P, Yang S, Lu D, Xie J, Ho TV, Tsark WM, Wang C, Horne DA, Riggs AD, Yip ML, Shi Y. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8. doi: 10.1073/pnas.1219181110. Epub 2012 Dec 3. PubMed PMID: 23213213; PubMed Central PMCID: PMC3529047.

4: Boer VM, Daran JM, Almering MJ, de Winde JH, Pronk JT. Contribution of the Saccharomyces cerevisiae transcriptional regulator Leu3p to physiology and gene expression in nitrogen- and carbon-limited chemostat cultures. FEMS Yeast Res. 2005 Jul;5(10):885-97. PubMed PMID: 15949974.

5: Adachi K, Hashimoto T, Ishihara S, Fujishiro H, Sato S, Sato H, Amano Y, Hattori S, Kinoshita Y. Comparison of five-day Helicobacter pylori eradication regimens: rabeprazole-based and omeprazole-based regimens with and without omeprazole pretreatment. Curr Ther Res Clin Exp. 2003 Jul;64(7):412-21. doi: 10.1016/S0011-393X(03)00120-6. PubMed PMID: 24944392; PubMed Central PMCID: PMC4053033.

6: Goethals K, Leyman B, Van Den Eede G, Van Montagu M, Holsters M. An Azorhizobium caulinodans ORS571 locus involved in lipopolysaccharide production and nodule formation on Sesbania rostrata stems and roots. J Bacteriol. 1994 Jan;176(1):92-9. PubMed PMID: 7506708; PubMed Central PMCID: PMC205018.