Remodelin HBr
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MedKoo CAT#: 317135

CAS#: 1622921-15-6

Description: Remodelin is a cell-permeable, potent, and stable analog of CPTH2. Remodelin inhibits acetyl-transferase NAT10, a nucleolar N-acetyltransferase involved in stabilization of microtubules. Remodelin is a cell-permeable, potent, and stable analog of CPTH2. Remodelin was found to correct cell defects associated with progeria, restoring and improving nuclear shape and reducing the DNA damage believed to be associated with mutations in the gene for laminin A.


Chemical Structure

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Remodelin HBr
CAS# 1622921-15-6

Theoretical Analysis

MedKoo Cat#: 317135
Name: Remodelin HBr
CAS#: 1622921-15-6
Chemical Formula: C15H15BrN4S
Exact Mass:
Molecular Weight: 363.28
Elemental Analysis: C, 49.59; H, 4.16; Br, 22.00; N, 15.42; S, 8.83

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same day
25.0mg USD 150.0 Same day
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 550.0 Same day
500.0mg USD 750.0 Same day
1.0g USD 950.0 Same day
2.0g USD 1650.0 Same day
5.0g USD 2650.0 Same day
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Synonym: Remodelin HBr; Remodelin Hydrobromide

IUPAC/Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile Hydrobromide

InChi Key: XNWBCMSPDCSWSD-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14N4S.BrH/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13;/h5-8,10H,1-4H2,(H,17,19);1H

SMILES Code: N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 363.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: de Carlo TE, Chin AT, Bonini Filho MA, Adhi M, Branchini L, Salz DA, Baumal CR, Crawford C, Reichel E, Witkin AJ, Duker JS, Waheed NK. DETECTION OF MICROVASCULAR CHANGES IN EYES OF PATIENTS WITH DIABETES BUT NOT CLINICAL DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2015 Oct 14. [Epub ahead of print] PubMed PMID: 26469537.

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3: Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice. Endocrinology. 2015 Oct 15:en20151709. [Epub ahead of print] PubMed PMID: 26469138.

4: Meï C, Michaud M, Cussac M, Albrieux C, Gros V, Maréchal E, Block MA, Jouhet J, Rébeillé F. Levels of polyunsaturated fatty acids correlate with growth rate in plant cell cultures. Sci Rep. 2015 Oct 15;5:15207. doi: 10.1038/srep15207. PubMed PMID: 26469123.

5: Kim SY, Sim CK, Tang H, Han W, Zhang K, Xu F. Acetylome Analysis Identifies SIRT1 Targets in mRNA-Processing and Chromatin-Remodeling in Mouse Liver. PLoS One. 2015 Oct 15;10(10):e0140619. doi: 10.1371/journal.pone.0140619. eCollection 2015. PubMed PMID: 26468954.

6: Kim KJ, Jung HY, Oh MH, Cho H, Lee JH, Lee HJ, Jang SH, Lee MS. Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features. J Gastric Cancer. 2015 Sep;15(3):201-8. doi: 10.5230/jgc.2015.15.3.201. Epub 2015 Sep 30. PubMed PMID: 26468418.

7: Kokoszka P, Markuszewski J, Łapaj Ł, Wierusz-Kozłowska M. Remodeling of bone tissue around the distal part of Zweymüller stem. Ortop Traumatol Rehabil. 2015 Sep 7;17(4):371-80. doi: 10.5604/15093492.1173379. PubMed PMID: 26468174.

8: Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, Surkova EA, Platonova IS, Titova ON. Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. Bull Exp Biol Med. 2015 Oct 15. [Epub ahead of print] PubMed PMID: 26468022.

9: Florence S, Sophie D, Renaud L. Biomarkers in the management of difficult asthma. Curr Top Med Chem. 2015 Oct 14. [Epub ahead of print] PubMed PMID: 26467509.

10: Mekonen HK, Hikspoors JP, Mommen G, Köhler SE, Lamers WH. Development of the ventral body wall in the human embryo. J Anat. 2015 Nov;227(5):673-85. doi: 10.1111/joa.12380. PubMed PMID: 26467243.

11: Staiano RI, Loffredo S, Borriello F, Iannotti FA, Piscitelli F, Orlando P, Secondo A, Granata F, Lepore MT, Fiorelli A, Varricchi G, Santini M, Triggiani M, Di Marzo V, Marone G. Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors. J Leukoc Biol. 2015 Oct 14. pii: jlb.3HI1214-584R. [Epub ahead of print] PubMed PMID: 26467187.

12: Dey D, Diaz Zamudio M, Schuhbaeck A, Juarez Orozco LE, Otaki Y, Gransar H, Li D, Germano G, Achenbach S, Berman DS, Meave A, Alexanderson E, Slomka PJ. Relationship Between Quantitative Adverse Plaque Features From Coronary Computed Tomography Angiography and Downstream Impaired Myocardial Flow Reserve by 13N-Ammonia Positron Emission Tomography: A Pilot Study. Circ Cardiovasc Imaging. 2015 Oct;8(10). pii: e003255. doi: 10.1161/CIRCIMAGING.115.003255. PubMed PMID: 26467104.

13: Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Int J Immunopathol Pharmacol. 2015 Oct 14. pii: 0394632015608248. [Epub ahead of print] PubMed PMID: 26467057.

14: Knorr RL, Lipowsky R, Dimova R. Autophagosome closure requires membrane scission. Autophagy. 2015 Oct 14:0. [Epub ahead of print] PubMed PMID: 26466816.

15: Hankins HM, Sere YY, Diab NS, Menon AK, Graham TR. Phosphatidylserine translocation at the yeast trans-Golgi network regulates protein sorting into exocytic vesicles. Mol Biol Cell. 2015 Oct 14. pii: mbc.E15-07-0487. [Epub ahead of print] PubMed PMID: 26466678.

16: Han S, Li YY, Chan BP. Protease inhibitors enhance extracellular collagen fibril deposition in human mesenchymal stem cells. Stem Cell Res Ther. 2015 Oct 15;6(1):197. doi: 10.1186/s13287-015-0191-1. PubMed PMID: 26466582.

17: Engelholm LH, Melander MC, Hald A, Persson M, Madsen DH, Jürgensen HJ, Johansson K, Nielsen C, Nørregaard KS, Ingvarsen SZ, Kjaer A, Trovik CS, Laerum OD, Bugge TH, Eide J, Behrendt N. Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180. J Pathol. 2015 Oct 15. doi: 10.1002/path.4661. [Epub ahead of print] PubMed PMID: 26466547.

18: El-Najjar N, Orsó E, Wallner S, Liebisch G, Schmitz G. Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. PLoS One. 2015 Oct 14;10(10):e0140683. doi: 10.1371/journal.pone.0140683. eCollection 2015. PubMed PMID: 26466367.

19: Zaragatski E, Grommes J, Schurgers LJ, Langer S, Kennes L, Tamm M, Koeppel TA, Kranz J, Hackhofer T, Arakelyan K, Jacobs MJ, Kokozidou M. Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment? Kidney Int. 2015 Oct 14. doi: 10.1038/ki.2015.298. [Epub ahead of print] PubMed PMID: 26466318.

20: Rustagi Y, Jaiswal HK, Rawal K, Kundu GC, Rani V. Comparative Characterization of Cardiac Development Specific microRNAs: Fetal Regulators for Future. PLoS One. 2015 Oct 14;10(10):e0139359. doi: 10.1371/journal.pone.0139359. eCollection 2015. PubMed PMID: 26465880.