WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522435
CAS#: 1118807-13-8
Description: KY02111 is a potent and selective inhibitor of Wnt. KY02111 promotes differentiation of hPSCs by inhibiting WNT signaling that is distinct. KY 02111 may by targeting the downstream from GSK3βand APC in β-catenin destruction complex. KY02111 promotes cardiac differentiation of hPSCs and human embryonic stem cells into cardiomyocytes.
MedKoo Cat#: 522435
Name: KY02111
CAS#: 1118807-13-8
Chemical Formula: C18H17ClN2O3S
Exact Mass: 376.06484
Molecular Weight: 376.86
Elemental Analysis: C, 57.37; H, 4.55; Cl, 9.41; N, 7.43; O, 12.74; S, 8.51
KY02111, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: KY02111; KY 02111; KY-02111
IUPAC/Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
InChi Key: LXFKEVQQSKQXPR-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17ClN2O3S/c1-23-14-7-3-11(9-15(14)24-2)4-8-17(22)21-18-20-13-6-5-12(19)10-16(13)25-18/h3,5-7,9-10H,4,8H2,1-2H3,(H,20,21,22)
SMILES Code: O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
The following data is based on the product molecular weight 376.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P. Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells. Exp Eye Res. 2015 Mar;132:174-8. doi: 10.1016/j.exer.2015.01.025. Epub 2015 Jan 30. PubMed PMID: 25639201; PubMed Central PMCID: PMC4352377.
2: Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60. doi: 10.1016/j.celrep.2012.09.015. Epub 2012 Oct 25. PubMed PMID: 23103164.