KY02111
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MedKoo CAT#: 522435

CAS#: 1118807-13-8

Description: KY02111 is a potent and selective inhibitor of Wnt. KY02111 promotes differentiation of hPSCs by inhibiting WNT signaling that is distinct. KY 02111 may by targeting the downstream from GSK3βand APC in β-catenin destruction complex. KY02111 promotes cardiac differentiation of hPSCs and human embryonic stem cells into cardiomyocytes.


Chemical Structure

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KY02111
CAS# 1118807-13-8

Theoretical Analysis

MedKoo Cat#: 522435
Name: KY02111
CAS#: 1118807-13-8
Chemical Formula: C18H17ClN2O3S
Exact Mass: 376.06484
Molecular Weight: 376.86
Elemental Analysis: C, 57.37; H, 4.55; Cl, 9.41; N, 7.43; O, 12.74; S, 8.51

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 Same day
25.0mg USD 250.0 Same day
50.0mg USD 450.0 Same day
100.0mg USD 650.0 Same day
200.0mg USD 950.0 Same day
500.0mg USD 1250.0 Same day
1.0g USD 2150.0 2 Weeks
2.0g USD 3650.0 2 Weeks
5.0g USD 6450.0 2 Weeks
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Synonym: KY02111; KY 02111; KY-02111

IUPAC/Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide

InChi Key: LXFKEVQQSKQXPR-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClN2O3S/c1-23-14-7-3-11(9-15(14)24-2)4-8-17(22)21-18-20-13-6-5-12(19)10-16(13)25-18/h3,5-7,9-10H,4,8H2,1-2H3,(H,20,21,22)

SMILES Code: O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 376.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P. Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells. Exp Eye Res. 2015 Mar;132:174-8. doi: 10.1016/j.exer.2015.01.025. Epub 2015 Jan 30. PubMed PMID: 25639201; PubMed Central PMCID: PMC4352377.

2: Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60. doi: 10.1016/j.celrep.2012.09.015. Epub 2012 Oct 25. PubMed PMID: 23103164.

KY02111

10.0mg / USD 150.0