WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522434
Description: VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).
MedKoo Cat#: 522434
Chemical Formula: C20H12ClFN2O4
Exact Mass: 398.04696
Molecular Weight: 398.77
Elemental Analysis: C, 60.24; H, 3.03; Cl, 8.89; F, 4.76; N, 7.03; O, 16.05
VU0486321 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: VU0486321, VU-0486321, VU 0486321
IUPAC/Chemical Name: N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide
InChi Key: HHRZBUWNLICHOO-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
SMILES Code: FC1=C2C(C(N(C3=CC=C(NC(C4=C(C)C=CO4)=O)C=C3Cl)C2=O)=O)=CC=C1
The following data is based on the product molecular weight 398.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|