WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522434

CAS#: 1816301-67-3

Description: VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).

Chemical Structure

CAS# 1816301-67-3

Theoretical Analysis

MedKoo Cat#: 522434
Name: VU0486321
CAS#: 1816301-67-3
Chemical Formula: C20H12ClFN2O4
Exact Mass: 398.04696
Molecular Weight: 398.77
Elemental Analysis: C, 60.24; H, 3.03; Cl, 8.89; F, 4.76; N, 7.03; O, 16.05

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Synonym: VU0486321, VU-0486321, VU 0486321

IUPAC/Chemical Name: N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide


InChi Code: InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)

SMILES Code: FC1=C2C(C(N(C3=CC=C(NC(C4=C(C)C=CO4)=O)C=C3Cl)C2=O)=O)=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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