WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522433

CAS#: 1129669-05-1

Description: IM-12 is a cell-permeable indolylmaleimide that acts as a GSK-3β inhibitor. IM-12 is potent and selective enhances canonical Wnt signalling. IM-12 inhibits GSK-3β activity and subsequently increases β-catenin concentration significantly in hNPCs. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells.

Chemical Structure

CAS# 1129669-05-1

Theoretical Analysis

MedKoo Cat#: 522433
Name: IM-12
CAS#: 1129669-05-1
Chemical Formula: C22H20FN3O2
Exact Mass: 377.15396
Molecular Weight: 377.42
Elemental Analysis: C, 70.01; H, 5.34; F, 5.03; N, 11.13; O, 8.48

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2650.0 2 Weeks
2.0g USD 3950.0 2 Weeks
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Synonym: IM-12; IM12; IM 12

IUPAC/Chemical Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione


InChi Code: InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3

SMILES Code: FC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 377.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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10.0mg / Ask price