WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317130
CAS#: 924416-43-3
Description: AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease.
MedKoo Cat#: 317130
Name: AdipoRon
CAS#: 924416-43-3
Chemical Formula: C27H28N2O3
Exact Mass: 428.20999
Molecular Weight: 428.52
Elemental Analysis: C, 75.68; H, 6.59; N, 6.54; O, 11.20
Synonym: AdipoRon;
IUPAC/Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
SMILES Code: O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4
Appearance: Solid powder
Purity: >97% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 428.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Malih S, Najafi R. AdipoRon: a possible drug for colorectal cancer prevention? Tumour Biol. 2015 Aug 18. [Epub ahead of print] PubMed PMID: 26282004.
2: Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. doi: 10.1152/ajpendo.00577.2014. Epub 2015 Jun 2. PubMed PMID: 26037251; PubMed Central PMCID: PMC4525114.
3: Dib J, Schlörer N, Schänzer W, Thevis M. Studies on the collision-induced dissociation of adipoR agonists after electrospray ionization and their implementation in sports drug testing. J Mass Spectrom. 2015 Feb;50(2):407-17. doi: 10.1002/jms.3545. PubMed PMID: 25800023.
4: Lee S, Kwak HB. Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil. 2014 Apr 30;10(2):54-9. doi: 10.12965/jer.140100. eCollection 2014 Apr. Review. PubMed PMID: 24877038; PubMed Central PMCID: PMC4025550.
5: Holland WL, Scherer PE. Cell Biology. Ronning after the adiponectin receptors. Science. 2013 Dec 20;342(6165):1460-1. doi: 10.1126/science.1249077. PubMed PMID: 24357309; PubMed Central PMCID: PMC4084614.
6: Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. doi: 10.1038/nature12656. Epub 2013 Oct 30. PubMed PMID: 24172895.
