4-(Trifluoromethyl)phenylboronic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 610230

CAS#: 128796-39-4

Description: 4-(Trifluoromethyl)phenylboronic acid undergoes direct cross-coupling with allyl alcohols. One use of this drug is to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones. It contains varying amounts of anhydride.

Price and Availability


USD 1250

USD 1950

USD 3950

4-(Trifluoromethyl)phenylboronic acid, purity > 98%, is in stock. Current shipping out time is about 10 days after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 610230
Name: 4-(Trifluoromethyl)phenylboronic acid
CAS#: 128796-39-4
Chemical Formula: C7H6BF3O2
Exact Mass: 190.04129
Molecular Weight: 189.93
Elemental Analysis: C, 44.27; H, 3.18; B, 5.69; F, 30.01; O, 16.85

Synonym: α,α,α-Trifluoro-p-tolylboronic acid, 4-(Trifluoromethyl)benzeneboronic acid, [p-(Trifluoromethyl)phenyl]boronic acid

IUPAC/Chemical Name: [4-(trifluoromethyl)phenyl]boronic acid


InChi Code: InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H

SMILES Code: B(C1=CC=C(C=C1)C(F)(F)F)(O)O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Cao KS, Bian HX, Zheng WH. Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles. Org Biomol Chem. 2015 Jun 21;13(23):6449-52. doi: 10.1039/c5ob00653h. Epub 2015 May 14. PubMed PMID: 25971529.

2: Christinat N, Scopelliti R, Severin K. Boron-based rotaxanes by multicomponent self-assembly. Chem Commun (Camb). 2008 Aug 21;(31):3660-2. doi: 10.1039/b805437a. Epub 2008 Jun 11. PubMed PMID: 18665291.

3: Maki T, Ishihara K, Yamamoto H. 4,5,6,7-Tetrachlorobenzo[d][1,3,2]dioxaborol- 2-ol as an effective catalyst for the amide condensation of sterically demanding carboxylic acids. Org Lett. 2006 Mar 30;8(7):1431-4. PubMed PMID: 16562909.

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5: Jordan F, Polgar L, Tous G. Proton magnetic resonance studies of the states of ionization of histidines in native and modified subtilisins. Biochemistry. 1985 Dec 17;24(26):7711-7. PubMed PMID: 3912007.

6: Poole CF, Johansson L, Vessman J. Formation of electron-capturing derivatives of alprenolol by transboronation: application to the determination of alprenolol in plasma. J Chromatogr. 1980 Jun 27;194(3):365-77. PubMed PMID: 7391216.