C646
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MedKoo CAT#: 407171

CAS#: 328968-36-1

Description: C646 is a potent histone acetyltransferase p300 inhibitor. C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. C646 radiosensitizes lung cancer cells by enhancing mitotic catastrophe. C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Note: this molecule exists as a mixture of cis- and trans- isomers.


Chemical Structure

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C646
CAS# 328968-36-1

Theoretical Analysis

MedKoo Cat#: 407171
Name: C646
CAS#: 328968-36-1
Chemical Formula: C24H19N3O6
Exact Mass: 445.12739
Molecular Weight: 445.43
Elemental Analysis: C, 64.72; H, 4.30; N, 9.43; O, 21.55

Price and Availability

Size Price Availability Quantity
5.0mg USD 120.0 Same day
100.0mg USD 350.0 2 Weeks
200.0mg USD 650.0 2 Weeks
500.0mg USD 1450.0 2 Weeks
1.0g USD 1950.0 2 Weeks
2.0g USD 3250.0 2 Weeks
5.0g USD 5250.0 2 Weeks
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Synonym: C646; C-646; C 646.

IUPAC/Chemical Name: (E)-4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

InChi Key: HEKJYZZSCQBJGB-XDHOZWIPSA-N

InChi Code: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+

SMILES Code: O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1

Appearance: Orange to red solid powder

Purity: >98% (Note: this molecule exists as a mixture of cis- and trans- isomers)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 445.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang Y, Liu K, Liang Y, Chen Y, Chen Y, Gong Y. Histone acetyltransferase
inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal
mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Int J
Clin Exp Pathol. 2015 Mar 1;8(3):2746-54. eCollection 2015. PubMed PMID:
26045780; PubMed Central PMCID: PMC4440089.

2: Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N,
Nakano T, Kohno T. C646, a selective small molecule inhibitor of histone
acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic
catastrophe. Radiother Oncol. 2014 May;111(2):222-7. doi:
10.1016/j.radonc.2014.03.015. Epub 2014 Apr 17. PubMed PMID: 24746574.

3: Gao XN, Lin J, Ning QY, Gao L, Yao YS, Zhou JH, Li YH, Wang LL, Yu L. A
histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and
apoptosis selectively in AML1-ETO-positive AML cells. PLoS One. 2013;8(2):e55481.
doi: 10.1371/journal.pone.0055481. Epub 2013 Feb 4. PubMed PMID: 23390536; PubMed
Central PMCID: PMC3563640.

C646

5.0mg / USD 120.0