WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407170
Description: MCB-613 is a potent Steroid Receptor Coactivator Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. MCB-613 can super-stimulate SRCs' transcriptional activity. MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 selectively induce excessive stress in cancer cells. Over-stimulating the SRC oncogenic program can be an effective strategy to kill cancer cells. By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics.
MedKoo Cat#: 407170
Chemical Formula: C19H19N3O
Exact Mass: 305.15281
Molecular Weight: 305.38
Elemental Analysis: C, 74.73; H, 6.27; N, 13.76; O, 5.24
MCB-613, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: MCB-613; MCB 613; MCB613.
IUPAC/Chemical Name: (3E,5E)-1-ethyl-3,5-bis(pyridin-3-ylmethylene)piperidin-4-one
InChi Key: LPGYWNGKCLRDNO-BEQMOXJMSA-N
InChi Code: InChI=1S/C19H19N3O/c1-2-22-13-17(9-15-5-3-7-20-11-15)19(23)18(14-22)10-16-6-4-8-21-12-16/h3-12H,2,13-14H2,1H3/b17-9+,18-10+
SMILES Code: O=C(/C(CN(CC)C/1)=C/C2=CC=CN=C2)C1=C\C3=CN=CC=C3
The following data is based on the product molecular weight 305.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Overstimulation Fatal for Cancer Cells. Cancer Discov. 2015 Aug 19. [Epub
ahead of print] PubMed PMID: 26290253.
2: Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao
L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor
Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads
to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52. doi:
10.1016/j.ccell.2015.07.005. PubMed PMID: 26267537; PubMed Central PMCID: