WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407170

CAS#: 1162656-22-5

Description: MCB-613 is a potent Steroid Receptor Coactivator Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. MCB-613 can super-stimulate SRCs' transcriptional activity. MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 selectively induce excessive stress in cancer cells. Over-stimulating the SRC oncogenic program can be an effective strategy to kill cancer cells. By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics.

Chemical Structure

CAS# 1162656-22-5

Theoretical Analysis

MedKoo Cat#: 407170
Name: MCB-613
CAS#: 1162656-22-5
Chemical Formula: C19H19N3O
Exact Mass: 305.15281
Molecular Weight: 305.38
Elemental Analysis: C, 74.73; H, 6.27; N, 13.76; O, 5.24

Price and Availability

Size Price Availability Quantity
100.0mg USD 190.0 2 Weeks
200.0mg USD 350.0 2 Weeks
500.0mg USD 750.0 2 Weeks
1.0g USD 1250.0 2 Weeks
2.0g USD 2150.0 2 Weeks
5.0g USD 3950.0 2 Weeks
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Synonym: MCB-613; MCB 613; MCB613.

IUPAC/Chemical Name: (3E,5E)-1-ethyl-3,5-bis(pyridin-3-ylmethylene)piperidin-4-one


InChi Code: InChI=1S/C19H19N3O/c1-2-22-13-17(9-15-5-3-7-20-11-15)19(23)18(14-22)10-16-6-4-8-21-12-16/h3-12H,2,13-14H2,1H3/b17-9+,18-10+

SMILES Code: O=C(/C(CN(CC)C/1)=C/C2=CC=CN=C2)C1=C\C3=CN=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 305.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Overstimulation Fatal for Cancer Cells. Cancer Discov. 2015 Aug 19. [Epub
ahead of print] PubMed PMID: 26290253.

2: Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao
L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor
Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads
to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52. doi:
10.1016/j.ccell.2015.07.005. PubMed PMID: 26267537; PubMed Central PMCID:


100.0mg / USD 190.0