WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407169
CAS#: 724741-75-7
Description: STE31 is a potent glucose transporter 1 (GLUT1). STF31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with STF31 inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.
MedKoo Cat#: 407169
Name: STF31
CAS#: 724741-75-7
Chemical Formula: C23H25N3O3S
Exact Mass: 423.16166
Molecular Weight: 423.53
Elemental Analysis: C, 65.23; H, 5.95; N, 9.92; O, 11.33; S, 7.57
Synonym: STF31; STF-31; STF 31.
IUPAC/Chemical Name: 4-(((4-(tert-butyl)phenyl)sulfonamido)methyl)-N-(pyridin-3-yl)benzamide
InChi Key: NGQPRVWTFNBUHA-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)
SMILES Code: O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 423.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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Q, Sahoo D, Hogg N, Boheler KR, Corbett JA, Gundry RL. Inhibition of an NAD⁺
salvage pathway provides efficient and selective toxicity to human pluripotent
stem cells. Stem Cells Transl Med. 2015 May;4(5):483-93. doi:
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Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B, Gundry RL. A human
pluripotent stem cell surface N-glycoproteome resource reveals markers,
extracellular epitopes, and drug targets. Stem Cell Reports. 2014 Jun
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Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular
target of STF-31-like small-molecule probes. ACS Chem Biol. 2014 Oct
17;9(10):2247-54. doi: 10.1021/cb500347p. Epub 2014 Aug 7. PubMed PMID: 25058389;
PubMed Central PMCID: PMC4201331.
4: Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi
JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny
WA, Hay MP, Giaccia AJ. Targeting GLUT1 and the Warburg effect in renal cell
carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug
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