STF31
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407169

CAS#: 724741-75-7

Description: STE31 is a potent glucose transporter 1 (GLUT1). STF31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with STF31 inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.


Chemical Structure

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STF31
CAS# 724741-75-7

Theoretical Analysis

MedKoo Cat#: 407169
Name: STF31
CAS#: 724741-75-7
Chemical Formula: C23H25N3O3S
Exact Mass: 423.16166
Molecular Weight: 423.53
Elemental Analysis: C, 65.23; H, 5.95; N, 9.92; O, 11.33; S, 7.57

Size Price Shipping out time Quantity
50mg USD 150 Same day
100mg USD 250 Same day
200mg USD 450 Same day
500mg USD 950 Same day
1g USD 1650 Same day
2g USD 2650 Same day
5g USD 4650 Same day
Inquire bulk and customized quantity

Pricing updated 2021-03-05. Prices are subject to change without notice.

STF31, purity > 98%, is in stock. Same day shipping after order is received.

Synonym: STF31; STF-31; STF 31.

IUPAC/Chemical Name: 4-(((4-(tert-butyl)phenyl)sulfonamido)methyl)-N-(pyridin-3-yl)benzamide

InChi Key: NGQPRVWTFNBUHA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)

SMILES Code: O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 423.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kropp EM, Oleson BJ, Broniowska KA, Bhattacharya S, Chadwick AC, Diers AR, Hu
Q, Sahoo D, Hogg N, Boheler KR, Corbett JA, Gundry RL. Inhibition of an NAD⁺
salvage pathway provides efficient and selective toxicity to human pluripotent
stem cells. Stem Cells Transl Med. 2015 May;4(5):483-93. doi:
10.5966/sctm.2014-0163. Epub 2015 Apr 1. PubMed PMID: 25834119; PubMed Central
PMCID: PMC4414215.

2: Boheler KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Bausch-Fluck D,
Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B, Gundry RL. A human
pluripotent stem cell surface N-glycoproteome resource reveals markers,
extracellular epitopes, and drug targets. Stem Cell Reports. 2014 Jun
6;3(1):185-203. doi: 10.1016/j.stemcr.2014.05.002. eCollection 2014 Jul 8. PubMed
PMID: 25068131; PubMed Central PMCID: PMC4110789.

3: Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH,
Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular
target of STF-31-like small-molecule probes. ACS Chem Biol. 2014 Oct
17;9(10):2247-54. doi: 10.1021/cb500347p. Epub 2014 Aug 7. PubMed PMID: 25058389;
PubMed Central PMCID: PMC4201331.

4: Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi
JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny
WA, Hay MP, Giaccia AJ. Targeting GLUT1 and the Warburg effect in renal cell
carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug
3;3(94):94ra70. doi: 10.1126/scitranslmed.3002394. PubMed PMID: 21813754; PubMed
Central PMCID: PMC3683134.