Fenebrutinib free base
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MedKoo CAT#: 206475

CAS#: 1434048-34-6 (free base)

Description: Fenebrutinib, also known as GDC-0853, is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.

Chemical Structure

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Fenebrutinib free base
CAS# 1434048-34-6 (free base)
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 206475
Name: Fenebrutinib free base
CAS#: 1434048-34-6 (free base)
Chemical Formula: C37H44N8O4
Exact Mass: 664.3486
Molecular Weight: 664.811
Elemental Analysis: C, 66.85; H, 6.67; N, 16.86; O, 9.63

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 850 Same day
200mg USD 1450 Same day
500mg USD 2950 Same day
1g USD 4650 Same day
2g USD 7950 Same day
Inquire bulk and customized quantity
Pricing updated 2021-03-08. Prices are subject to change without notice.

Fenebrutinib (GDC-0853), purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 1434048-34-6 (free base)   2128304-54-9 (HCl)   2128304-53-8 (mesylate)   2128304-55-0 (sulfate)    

Synonym: GDC-0853; GDC 0853; GDC0853; RG-7845; RG7845; RG 7845; Fenebrutinib; Fenebrutinib free base;

IUPAC/Chemical Name: (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one

InChi Key: WNEODWDFDXWOLU-QHCPKHFHSA-N

InChi Code: InChI=1S/C37H44N8O4/c1-23-18-42(27-21-49-22-27)9-10-43(23)26-5-6-33(39-17-26)40-30-13-25(19-41(4)35(30)47)28-7-8-38-34(29(28)20-46)45-12-11-44-31(36(45)48)14-24-15-37(2,3)16-32(24)44/h5-8,13-14,17,19,23,27,46H,9-12,15-16,18,20-22H2,1-4H3,(H,39,40)/t23-/m0/s1

SMILES Code: O=C1C(N2CCN1C3=NC=CC(C(C=C4NC5=NC=C(N6[C@@H](C)CN(C7COC7)CC6)C=C5)=CN(C)C4=O)=C3CO)=CC8=C2CC(C)(C)C8

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 664.811 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Heteroarylpyridone and azapyridone compounds as inhibitors of BTK activity and their preparation
By Crawford, James John; Ortwine, Daniel Fred; Wei, Binqing; Young, Wendy B.
From PCT Int. Appl. (2013), WO 2013067274 A1 20130510.

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Fenebrutinib free base

10mg / USD 150


Additional Information

Note: Structure was from https://newdrugapprovals.org/2016/03/ ( visited on 4/7/2016)