WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522413
CAS#: 849773-63-3
Description: ARP-101 is a selective MMP-2 inhibitor that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 treatment was highly effective in inducing the formation of autophagosome and conversion of LC3I into LC3II. Moreover, ARP101-induced autophagy was completely blocked in mouse embryo fibroblasts that lacked autophagy related gene 5 (ATG5(-/-) MEF). ARP101 inhibited α-MSH-stimulated melanin synthesis and suppressed the expression of tyrosinase and TRP1 in immortalized mouse melanocytes. ARP101 also induced autophagy in melanocytes.
MedKoo Cat#: 522413
Name: ARP-101
CAS#: 849773-63-3
Chemical Formula: C20H26N2O5S
Exact Mass: 406.15624
Molecular Weight: 406.5
Elemental Analysis: C, 59.10; H, 6.45; N, 6.89; O, 19.68; S, 7.89
Synonym: ARP-101; ARP 101; ARP101.
IUPAC/Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
InChi Key: DGZZVIWCMGVHGV-LJQANCHMSA-N
InChi Code: InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
SMILES Code: CC(C)[C@@H](N(OC(C)C)S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)C(NO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 406.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kim ES, Jo YK, Park SJ, Chang H, Shin JH, Choi ES, Kim JB, Seok SH, Kim JS, Oh
JS, Kim MH, Lee EH, Cho DH. ARP101 inhibits α-MSH-stimulated melanogenesis by
regulation of autophagy in melanocytes. FEBS Lett. 2013 Dec 11;587(24):3955-60.
doi: 10.1016/j.febslet.2013.10.027. Epub 2013 Nov 1. PubMed PMID: 24188823.
2: Jo YK, Park SJ, Shin JH, Kim Y, Hwang JJ, Cho DH, Kim JC. ARP101, a selective
MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. Biochem
Biophys Res Commun. 2011 Jan 28;404(4):1039-43. doi: 10.1016/j.bbrc.2010.12.106.
Epub 2010 Dec 25. PubMed PMID: 21187062.
