WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206474
Description: RSM-932A, also known as TCD-717, is a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether novel mechanism of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory activity in the low nanomolar range. RSM-932A significantly reduced parasitemia and induced the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion, suggesting a delay of the parasite maturation stage.
MedKoo Cat#: 206474
Chemical Formula: C46H38Br2Cl2N4
Molecular Weight: 877.546
Elemental Analysis: C, 62.96; H, 4.36; Br, 18.21; Cl, 8.08; N, 6.38
Synonym: RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.
IUPAC/Chemical Name: 1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide
InChi Key: DGBVSSXGHKAASQ-UHFFFAOYSA-L
InChi Code: InChI=1S/C46H38Cl2N4.2BrH/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40;;/h3-30H,31-32H2,1-2H3;2*1H/q+2;;/p-2
SMILES Code: CN(C1=CC=C(Cl)C=C1)C(C2=C3C=CC=C2)=CC=[N+]3CC4=CC=C(C5=CC=C(C[N+]6=CC=C(N(C7=CC=C(Cl)C=C7)C)C8=C6C=CC=C8)C=C5)C=C4.[Br-].[Br-]
Appearance: White solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 877.546 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lacal JC, Campos JM. Preclinical characterization of RSM-932A, a novel
anticancer drug targeting the human choline kinase alpha, an enzyme involved in
increased lipid metabolism of cancer cells. Mol Cancer Ther. 2015 Jan;14(1):31-9.
doi: 10.1158/1535-7163.MCT-14-0531. Epub 2014 Dec 8. PubMed PMID: 25487918.
2: Zimmerman T, Moneriz C, Diez A, Bautista JM, Gómez Del Pulgar T, Cebrián A,
Lacal JC. Antiplasmodial activity and mechanism of action of RSM-932A, a
promising synergistic inhibitor of Plasmodium falciparum choline kinase.
Antimicrob Agents Chemother. 2013 Dec;57(12):5878-88. doi: 10.1128/AAC.00920-13.
Epub 2013 Sep 16. PubMed PMID: 24041883; PubMed Central PMCID: PMC3837925.
850807-63-5 ( RSM-932A)
850993-73-6 ( RSM-932A cation)