Adriforant

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522410

CAS#: 943057-12-3

Description: Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies.


Chemical Structure

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Adriforant
CAS# 943057-12-3

Theoretical Analysis

MedKoo Cat#: 522410
Name: Adriforant
CAS#: 943057-12-3
Chemical Formula: C13H22N6
Exact Mass: 262.19059
Molecular Weight: 262.36
Elemental Analysis: C, 59.51; H, 8.45; N, 32.03

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Synonym: ZPL-3893787; ZPL3893787; ZPL 3893787; ZPL-389; ZPL 389; ZPL389; PF-03893787; PF03893787; PF 03893787; PF-3893787; PF3893787; PF 3893787; Adriforant;

IUPAC/Chemical Name: (R)-N4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine

InChi Key: ISBHYKVAFKTATD-SNVBAGLBSA-N

InChi Code: InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1

SMILES Code: NC1=NC(N2CC[C@@H](NC)C2)=CC(NCC3CC3)=N1

Appearance: White to off-white solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 262.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Andaloussi M, Lim HD, van der Meer T, Sijm M, Poulie CB, de Esch IJ, Leurs R,
Smits RA. A novel series of histamine H4 receptor antagonists based on the
pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence
time with PF-3893787. Bioorg Med Chem Lett. 2013 May 1;23(9):2663-70. doi:
10.1016/j.bmcl.2013.02.091. Epub 2013 Mar 1. PubMed PMID: 23558237.

2: Salcedo C, Pontes C, Merlos M. Is the H4 receptor a new drug target for
allergies and asthma? Front Biosci (Elite Ed). 2013 Jan 1;5:178-87. Review.
PubMed PMID: 23276980.

3: Mowbray CE, Bell AS, Clarke NP, Collins M, Jones RM, Lane CA, Liu WL, Newman
SD, Paradowski M, Schenck EJ, Selby MD, Swain NA, Williams DH. Challenges of drug
discovery in novel target space. The discovery and evaluation of PF-3893787: a
novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov
1;21(21):6596-602. doi: 10.1016/j.bmcl.2011.07.125. Epub 2011 Aug 9. PubMed PMID:
21920751.