WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407164
Description: AGN-194310, also known as VTP-194310, is a pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR α, RARβ and RARγ, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR α, RARβ and RARγ, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+-grown cell lines with IC50 values of 16 ± 5nM for LNCaP cells; 18 ± 6nM for PC3 cells; and 34 ± 7nM for DU-145 cells. Apart from these, because of binding to and mediating the effects via RARs, AGN 194310 has been demonstrated to inhibit agonist-induced (TTNPB) differentiation of HL60 cells. AGN 194310 has also shown the accumulation of cell in G1 and the function of induced apoptosis.
MedKoo Cat#: 407164
Chemical Formula: C28H24O2S
Exact Mass: 424.1497
Molecular Weight: 424.56
Elemental Analysis: C, 79.21; H, 5.70; O, 7.54; S, 7.55
AGN-194310, purity > 98%, is in stock. The same day shipping after order received.
Synonym: AGN 194310; AGN194310; AGN-194310; VTP-194310; VTP 194310; VTP194310;
IUPAC/Chemical Name: 4-((4-(4-ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl)ethynyl)benzoic acid
InChi Key: LHUPKWKWYWOMSK-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30)
SMILES Code: O=C(O)C1=CC=C(C#CC2=CC(C(C3=CC=C(CC)C=C3)=CC(C)(C)S4)=C4C=C2)C=C1
The following data is based on the product molecular weight 424.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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