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MedKoo CAT#: 407163
CAS#: 873225-46-8 (free base)
Description: IKK-16 is a potent and slective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). KK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells.
MedKoo Cat#: 407163
Name: IKK-16 (free base)
CAS#: 873225-46-8 (free base)
Chemical Formula: C28H29N5OS
Exact Mass: 483.20928
Molecular Weight: 483.63
Elemental Analysis: C, 69.54; H, 6.04; N, 14.48; O, 3.31; S, 6.63
Related CAS #: 873225-46-8 (free base) 1186195-62-9 (HCl)
Synonym: IKK-16; IKK 16; IKK16; IKK-16
IUPAC/Chemical Name: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
InChi Key: BWZJBXAPRCVCKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)
SMILES Code: O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5
Related CAS#
873225-46-8 ( IKK-16 free base)
1186195-62-9 ( IKK-16 HCl salt).
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