Pluripotin
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MedKoo CAT#: 407160

CAS#: 839707-37-8

Description: Pluripotin, also known as SC-1, is a potent and selective activator of murine embryonic stem (ES) cell self-renewal. Pluripotin is a useful tool for studying cancer stem cell biology. Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Pluripotin works through dual inhibition of RasGAP and ERK1. Pluripotin may not only facilitate practical applications of stem cells in research and therapy, but also provide previously undescribed insights into the complex biology of stem cells.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 90 2 Weeks
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1550 2 Weeks
1g USD 2850 2 Weeks
2g USD 5450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

Pluripotin, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407160
Name: Pluripotin
CAS#: 839707-37-8
Chemical Formula: C27H25F3N8O2
Exact Mass: 550.20526
Molecular Weight: 550.55
Elemental Analysis: C, 58.90; H, 4.58; F, 10.35; N, 20.35; O, 5.81


Synonym: SC-1; SC 1; SC1; Pluripotin

IUPAC/Chemical Name: N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide

InChi Key: NBZFRTJWEIHFPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)

SMILES Code: O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5


Technical Data

Appearance:
White to off-white solid powder

Purity:
>97% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Lin CJ, Amano T, Tang Y, Tian X. Improved derivation efficiency and pluripotency of stem cells from the refractory inbred C57BL/6 mouse strain by small molecules. PLoS One. 2014 Sep 11;9(9):e106916. doi: 10.1371/journal.pone.0106916. eCollection 2014. PubMed PMID: 25211343; PubMed Central PMCID: PMC4161378.

2: Du J, Wu Y, Liu Y, Ai Z, Wu H, Shi X, Guo Z, Zhang Y. E-cadherin is critical for SC1-induced colony growth of F9 embryonic carcinoma cells. Cell Physiol Biochem. 2014;33(2):501-12. doi: 10.1159/000358630. Epub 2014 Feb 14. PubMed PMID: 24556957.

3: Li W, Li K, Wei W, Ding S. Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell. 2013 Sep 5;13(3):270-83. doi: 10.1016/j.stem.2013.08.002. Review. PubMed PMID: 24012368; PubMed Central PMCID: PMC3898630.

4: Al-Habib M, Yu Z, Huang GT. Small molecules affect human dental pulp stem cell properties via multiple signaling pathways. Stem Cells Dev. 2013 Sep 1;22(17):2402-13. doi: 10.1089/scd.2012.0426. Epub 2013 May 24. PubMed PMID: 23573877; PubMed Central PMCID: PMC3749717.

5: Mertins SD, Scudiero DA, Hollingshead MG, Divelbiss RD Jr, Alley MC, Monks A, Covell DG, Hite KM, Salomon DS, Niederhuber JE. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8(2):e57099. doi: 10.1371/journal.pone.0057099. Epub 2013 Feb 21. PubMed PMID: 23437320; PubMed Central PMCID: PMC3578829.

6: Wu Y, Guo Z, Liu Y, Tang B, Wang Y, Yang L, Du J, Zhang Y. Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells. Mol Biol Rep. 2013 Apr;40(4):2897-906. doi: 10.1007/s11033-012-2305-5. Epub 2012 Dec 20. PubMed PMID: 23254757.

7: Duan H, Wang Y, Yang L, Qu M, Wang Q, Shi W, Zhou Q. Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Exp Eye Res. 2012 Jul;100:52-8. doi: 10.1016/j.exer.2012.04.012. Epub 2012 Apr 30. PubMed PMID: 22564971.

8: Pieters T, Haenebalcke L, Hochepied T, D'Hont J, Haigh JJ, van Roy F, van Hengel J. Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells. Stem Cell Rev. 2012 Sep;8(3):768-78. doi: 10.1007/s12015-011-9323-x. PubMed PMID: 22011883; PubMed Central PMCID: PMC3412084.

9: Xiong W, Gao Y, Cheng X, Martin C, Wu D, Yao S, Kim MJ, Liu Y. The use of SC1 (Pluripotin) to support mESC self-renewal in the absence of LIF. J Vis Exp. 2009 Nov 18;(33). pii: 1550. doi: 10.3791/1550. PubMed PMID: 19924098; PubMed Central PMCID: PMC3157853.

10: Kochegarov A. Small molecules for stem cells. Expert Opin Ther Pat. 2009 Mar;19(3):275-81. doi: 10.1517/13543770802709010. Review. PubMed PMID: 19441903.

11: Yang W, Wei W, Shi C, Zhu J, Ying W, Shen Y, Ye X, Fang L, Duo S, Che J, Shen H, Ding S, Deng H. Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells. 2009 Feb;27(2):383-9. doi: 10.1634/stemcells.2008-0974. PubMed PMID: 19056907.

12: Letso RR, Stockwell BR. Chemical biology: renewing embryonic stem cells. Nature. 2006 Dec 7;444(7120):692-3. PubMed PMID: 17151647.

13: Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. Epub 2006 Nov 6. PubMed PMID: 17088537; PubMed Central PMCID: PMC1859921.