WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407160
CAS#: 839707-37-8
Description: Pluripotin, also known as SC-1, is a potent and selective activator of murine embryonic stem (ES) cell self-renewal. Pluripotin is a useful tool for studying cancer stem cell biology. Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Pluripotin works through dual inhibition of RasGAP and ERK1. Pluripotin may not only facilitate practical applications of stem cells in research and therapy, but also provide previously undescribed insights into the complex biology of stem cells.
MedKoo Cat#: 407160
Name: Pluripotin
CAS#: 839707-37-8
Chemical Formula: C27H25F3N8O2
Exact Mass: 550.20526
Molecular Weight: 550.55
Elemental Analysis: C, 58.90; H, 4.58; F, 10.35; N, 20.35; O, 5.81
Synonym: SC-1; SC 1; SC1; Pluripotin
IUPAC/Chemical Name: N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide
InChi Key: NBZFRTJWEIHFPF-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
SMILES Code: O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
1: Lin CJ, Amano T, Tang Y, Tian X. Improved derivation efficiency and pluripotency of stem cells from the refractory inbred C57BL/6 mouse strain by small molecules. PLoS One. 2014 Sep 11;9(9):e106916. doi: 10.1371/journal.pone.0106916. eCollection 2014. PubMed PMID: 25211343; PubMed Central PMCID: PMC4161378.
2: Du J, Wu Y, Liu Y, Ai Z, Wu H, Shi X, Guo Z, Zhang Y. E-cadherin is critical for SC1-induced colony growth of F9 embryonic carcinoma cells. Cell Physiol Biochem. 2014;33(2):501-12. doi: 10.1159/000358630. Epub 2014 Feb 14. PubMed PMID: 24556957.
3: Li W, Li K, Wei W, Ding S. Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell. 2013 Sep 5;13(3):270-83. doi: 10.1016/j.stem.2013.08.002. Review. PubMed PMID: 24012368; PubMed Central PMCID: PMC3898630.
4: Al-Habib M, Yu Z, Huang GT. Small molecules affect human dental pulp stem cell properties via multiple signaling pathways. Stem Cells Dev. 2013 Sep 1;22(17):2402-13. doi: 10.1089/scd.2012.0426. Epub 2013 May 24. PubMed PMID: 23573877; PubMed Central PMCID: PMC3749717.
5: Mertins SD, Scudiero DA, Hollingshead MG, Divelbiss RD Jr, Alley MC, Monks A, Covell DG, Hite KM, Salomon DS, Niederhuber JE. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8(2):e57099. doi: 10.1371/journal.pone.0057099. Epub 2013 Feb 21. PubMed PMID: 23437320; PubMed Central PMCID: PMC3578829.
6: Wu Y, Guo Z, Liu Y, Tang B, Wang Y, Yang L, Du J, Zhang Y. Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells. Mol Biol Rep. 2013 Apr;40(4):2897-906. doi: 10.1007/s11033-012-2305-5. Epub 2012 Dec 20. PubMed PMID: 23254757.
7: Duan H, Wang Y, Yang L, Qu M, Wang Q, Shi W, Zhou Q. Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Exp Eye Res. 2012 Jul;100:52-8. doi: 10.1016/j.exer.2012.04.012. Epub 2012 Apr 30. PubMed PMID: 22564971.
8: Pieters T, Haenebalcke L, Hochepied T, D'Hont J, Haigh JJ, van Roy F, van Hengel J. Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells. Stem Cell Rev. 2012 Sep;8(3):768-78. doi: 10.1007/s12015-011-9323-x. PubMed PMID: 22011883; PubMed Central PMCID: PMC3412084.
9: Xiong W, Gao Y, Cheng X, Martin C, Wu D, Yao S, Kim MJ, Liu Y. The use of SC1 (Pluripotin) to support mESC self-renewal in the absence of LIF. J Vis Exp. 2009 Nov 18;(33). pii: 1550. doi: 10.3791/1550. PubMed PMID: 19924098; PubMed Central PMCID: PMC3157853.
10: Kochegarov A. Small molecules for stem cells. Expert Opin Ther Pat. 2009 Mar;19(3):275-81. doi: 10.1517/13543770802709010. Review. PubMed PMID: 19441903.
11: Yang W, Wei W, Shi C, Zhu J, Ying W, Shen Y, Ye X, Fang L, Duo S, Che J, Shen H, Ding S, Deng H. Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells. 2009 Feb;27(2):383-9. doi: 10.1634/stemcells.2008-0974. PubMed PMID: 19056907.
12: Letso RR, Stockwell BR. Chemical biology: renewing embryonic stem cells. Nature. 2006 Dec 7;444(7120):692-3. PubMed PMID: 17151647.
13: Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. Epub 2006 Nov 6. PubMed PMID: 17088537; PubMed Central PMCID: PMC1859921.
