UM729

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522397

CAS#: 1448723-60-1

Description: UM729 is an enhancer of AhR antagonists. UM-729 enhances the self-renewal of human hematopoietic stem cells in vitro. UM729 does not inhibit the aryl hydrocarbon receptor (AhR) pathway, but has been shown to collaborate with AHR antagonists in preventing differentiation of acute myeloid leukemia (AML) cells in culture. UM729 was originally discovered in a screen of compounds capable of promoting human CD34+ cell expansion. UM-729 may be used for the enhancement of human HSC self-renewal in culture, and for the maintenance of human leukemia stem cell (LSC) activity in culture.


Chemical Structure

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UM729
CAS# 1448723-60-1

Theoretical Analysis

MedKoo Cat#: 522397
Name: UM729
CAS#: 1448723-60-1
Chemical Formula: C20H25N5O2
Exact Mass: 367.20083
Molecular Weight: 367.45
Elemental Analysis: C, 65.37; H, 6.86; N, 19.06; O, 8.71

Size Price Shipping out time Quantity
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Pricing updated 2021-02-26. Prices are subject to change without notice.

UM729 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: UM729, UM-729, UM 729

IUPAC/Chemical Name: methyl 4-((3-(piperidin-1-yl)propyl)amino)-9H-pyrimido[4,5-b]indole-7-carboxylate

InChi Key: SIBCJMZHJZDUNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25N5O2/c1-27-20(26)14-6-7-15-16(12-14)24-19-17(15)18(22-13-23-19)21-8-5-11-25-9-3-2-4-10-25/h6-7,12-13H,2-5,8-11H2,1H3,(H2,21,22,23,24)

SMILES Code: O=C(OC)C1=CC=C(C2=C(NCCCN3CCCCC3)N=CN=C2N4)C4=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nat Methods. 2014 Apr;11(4):436-42. doi: 10.1038/nmeth.2847. Epub 2014 Feb 23. PubMed PMID: 24562423.