WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522396
Description: SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. 15-PGDH is a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. SW033291 also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts.
MedKoo Cat#: 522396
Chemical Formula: C21H20N2OS3
Exact Mass: 412.07378
Molecular Weight: 412.58
Elemental Analysis: C, 61.13; H, 4.89; N, 6.79; O, 3.88; S, 23.31
SW033291, purity > 98%, is in stock . The same day shipping out after order is received.
Synonym: SW033291; SW 033291; SW 033291.
IUPAC/Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
InChi Key: LCYAYKSMOVLVRL-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
SMILES Code: NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
The following data is based on the product molecular weight 412.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE,
Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L,
Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C,
Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK,
Markowitz SD. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading
enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun
12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. PubMed PMID: 26068857; PubMed
Central PMCID: PMC4481126.