SW033291
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522396

CAS#: 459147-39-8

Description: SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. 15-PGDH is a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. SW033291 also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts.

Chemical Structure

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SW033291
CAS# 459147-39-8
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 522396
Name: SW033291
CAS#: 459147-39-8
Chemical Formula: C21H20N2OS3
Exact Mass: 412.07378
Molecular Weight: 412.58
Elemental Analysis: C, 61.13; H, 4.89; N, 6.79; O, 3.88; S, 23.31

Size Price Shipping out time Quantity
25mg USD 150 Same day
50mg USD 250 Same day
100mg USD 450 Same day
200mg USD 850 Same day
500mg USD 1550 Same day
1g USD 2650 Same day
2g USD 4650 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-08. Prices are subject to change without notice.

SW033291, purity > 98%, is in stock . The same day shipping out after order is received.

Synonym: SW033291; SW 033291; SW 033291.

IUPAC/Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine

InChi Key: LCYAYKSMOVLVRL-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3

SMILES Code: NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

Appearance:
Yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 412.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE,
Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L,
Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C,
Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK,
Markowitz SD. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading
enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun
12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. PubMed PMID: 26068857; PubMed
Central PMCID: PMC4481126.

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SW033291

25mg / USD 150