WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407159

CAS#: 1884220-36-3

Description: SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.

Chemical Structure

CAS# 1884220-36-3

Theoretical Analysis

MedKoo Cat#: 407159
Name: SBI0206965
CAS#: 1884220-36-3
Chemical Formula: C21H21BrN4O5
Exact Mass: 488.06953
Molecular Weight: 489.33
Elemental Analysis: C, 51.55; H, 4.33; Br, 16.33; N, 11.45; O, 16.35

Price and Availability

Size Price Availability Quantity
10.0mg USD 120.0 Same day
25.0mg USD 190.0 Same day
50.0mg USD 350.0 Same day
100.0mg USD 550.0 Same day
200.0mg USD 850.0 Same day
500.0mg USD 1450.0 Same day
1.0g USD 2450.0 Same day
2.0g USD 3950.0 Same day
5.0g USD 7650.0 Same day
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Synonym: SBI0206965; SBI-0206965; SBI 0206965.

IUPAC/Chemical Name: 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide


InChi Code: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 489.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dual Inhibition of ULK1 and mTOR Enhances Tumor Cell Apoptosis. Cancer Discov.
2015 Sep;5(9):OF5. doi: 10.1158/2159-8290.CD-RW2015-127. Epub 2015 Jul 9. PubMed
PMID: 26159593.

2: Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ,
Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford
ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and
Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59(2):285-97. doi:
10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25. PubMed PMID: 26118643; PubMed
Central PMCID: PMC4530630.