WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407159
Description: SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.
MedKoo Cat#: 407159
Chemical Formula: C21H21BrN4O5
Exact Mass: 488.06953
Molecular Weight: 489.33
Elemental Analysis: C, 51.55; H, 4.33; Br, 16.33; N, 11.45; O, 16.35
SBI0206965, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).
Synonym: SBI0206965; SBI-0206965; SBI 0206965.
IUPAC/Chemical Name: 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
SMILES Code: O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
The following data is based on the product molecular weight 489.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dual Inhibition of ULK1 and mTOR Enhances Tumor Cell Apoptosis. Cancer Discov.
2015 Sep;5(9):OF5. doi: 10.1158/2159-8290.CD-RW2015-127. Epub 2015 Jul 9. PubMed
2: Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ,
Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford
ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and
Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59(2):285-97. doi:
10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25. PubMed PMID: 26118643; PubMed
Central PMCID: PMC4530630.