WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407159
CAS#: 1884220-36-3
Description: SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.
MedKoo Cat#: 407159
Name: SBI0206965
CAS#: 1884220-36-3
Chemical Formula: C21H21BrN4O5
Exact Mass: 488.06953
Molecular Weight: 489.33
Elemental Analysis: C, 51.55; H, 4.33; Br, 16.33; N, 11.45; O, 16.35
Synonym: SBI0206965; SBI-0206965; SBI 0206965.
IUPAC/Chemical Name: 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
SMILES Code: O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 489.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Dual Inhibition of ULK1 and mTOR Enhances Tumor Cell Apoptosis. Cancer Discov.
2015 Sep;5(9):OF5. doi: 10.1158/2159-8290.CD-RW2015-127. Epub 2015 Jul 9. PubMed
PMID: 26159593.
2: Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ,
Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford
ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and
Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59(2):285-97. doi:
10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25. PubMed PMID: 26118643; PubMed
Central PMCID: PMC4530630.
