HA130
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522395

CAS#: 1229652-21-4

Description: HA130 is a potent and selective autotaxin (ATX) inhibitor (IC50 = 28 nM). HA130 slows T cell migration across lymph node HEVs in vivo. Ex vivo, HA130 blunts the TEM-promoting activity of ATX, paralleling its in vivo effects.


Chemical Structure

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HA130
CAS# 1229652-21-4

Theoretical Analysis

MedKoo Cat#: 522395
Name: HA130
CAS#: 1229652-21-4
Chemical Formula: C24H19BFNO5S
Exact Mass: 463.1061
Molecular Weight: 463.29
Elemental Analysis: C, 62.22; H, 4.13; B, 2.33; F, 4.10; N, 3.02; O, 17.27; S, 6.92

Size Price Shipping out time Quantity
50mg USD 350 2 Weeks
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2450 2 Weeks
2g USD 3950 2 Weeks
5g USD 6450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

HA130, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: HA130; HA-130; HA 130.

IUPAC/Chemical Name: (Z)-(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N

InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-

SMILES Code: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer
cells. Cell Signal. 2013 Nov;25(11):2147-54. doi: 10.1016/j.cellsig.2013.07.001.
Epub 2013 Jul 6. PubMed PMID: 23838008.

2: Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ.
Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right
asymmetry in zebrafish. Development. 2012 Dec 1;139(23):4439-48. doi:
10.1242/dev.081745. Epub 2012 Oct 24. PubMed PMID: 23095890.

3: Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic
acid stimulates polarization, motility, and transendothelial migration of naive T
cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub
2012 Sep 7. PubMed PMID: 22962684; PubMed Central PMCID: PMC3509168.