HA130
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MedKoo CAT#: 522395

CAS#: 1229652-21-4

Description: HA130 is a potent and selective autotaxin (ATX) inhibitor (IC50 = 28 nM). HA130 slows T cell migration across lymph node HEVs in vivo. Ex vivo, HA130 blunts the TEM-promoting activity of ATX, paralleling its in vivo effects.


Chemical Structure

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HA130
CAS# 1229652-21-4

Theoretical Analysis

MedKoo Cat#: 522395
Name: HA130
CAS#: 1229652-21-4
Chemical Formula: C24H19BFNO5S
Exact Mass: 463.1061
Molecular Weight: 463.29
Elemental Analysis: C, 62.22; H, 4.13; B, 2.33; F, 4.10; N, 3.02; O, 17.27; S, 6.92

Price and Availability

Size Price Availability Quantity
50.0mg USD 350.0 2 Weeks
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3950.0 2 Weeks
5.0g USD 6450.0 2 Weeks
Bulk inquiry

Synonym: HA130; HA-130; HA 130.

IUPAC/Chemical Name: (Z)-(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N

InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-

SMILES Code: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 463.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer
cells. Cell Signal. 2013 Nov;25(11):2147-54. doi: 10.1016/j.cellsig.2013.07.001.
Epub 2013 Jul 6. PubMed PMID: 23838008.

2: Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ.
Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right
asymmetry in zebrafish. Development. 2012 Dec 1;139(23):4439-48. doi:
10.1242/dev.081745. Epub 2012 Oct 24. PubMed PMID: 23095890.

3: Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic
acid stimulates polarization, motility, and transendothelial migration of naive T
cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub
2012 Sep 7. PubMed PMID: 22962684; PubMed Central PMCID: PMC3509168.

HA130

50.0mg / USD 350.0