ISX-9
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522394

CAS#: 832115-62-5

Description: ISX-9 is a neurogenic agent. Isx-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. Isx-9 also improves hippocampal function, enhancing memory in the Morris water maze. Notably, Isx-9 enhances neurogenesis and memory without detectable increases in cellular or animal activity or vascularization. Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis.


Chemical Structure

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ISX-9
CAS# 832115-62-5

Theoretical Analysis

MedKoo Cat#: 522394
Name: ISX-9
CAS#: 832115-62-5
Chemical Formula: C11H10N2O2S
Exact Mass: 234.0463
Molecular Weight: 234.27
Elemental Analysis: C, 56.40; H, 4.30; N, 11.96; O, 13.66; S, 13.68

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same day
25.0mg USD 150.0 Same day
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1250.0 Same day
1.0g USD 1950.0 Same day
2.0g USD 2950.0 Same day
5.0g USD 4950.0 4 Weeks
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Synonym: ISX-9; ISX 9; ISX9; Isoxazole 9

IUPAC/Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

InChi Key: SYENTKHGMVKGAQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14)

SMILES Code: O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 234.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim MS, Hsieh J, Eisch AJ.
Functional and mechanistic exploration of an adult neurogenesis-promoting small
molecule. FASEB J. 2012 Aug;26(8):3148-62. doi: 10.1096/fj.11-201426. Epub 2012
Apr 27. PubMed PMID: 22542682; PubMed Central PMCID: PMC3405259.

ISX-9

10.0mg / USD 90.0