WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522394
CAS#: 832115-62-5
Description: ISX-9 is a neurogenic agent. Isx-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. Isx-9 also improves hippocampal function, enhancing memory in the Morris water maze. Notably, Isx-9 enhances neurogenesis and memory without detectable increases in cellular or animal activity or vascularization. Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis.
MedKoo Cat#: 522394
Name: ISX-9
CAS#: 832115-62-5
Chemical Formula: C11H10N2O2S
Exact Mass: 234.0463
Molecular Weight: 234.27
Elemental Analysis: C, 56.40; H, 4.30; N, 11.96; O, 13.66; S, 13.68
Synonym: ISX-9; ISX 9; ISX9; Isoxazole 9
IUPAC/Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
InChi Key: SYENTKHGMVKGAQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14)
SMILES Code: O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 234.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim MS, Hsieh J, Eisch AJ.
Functional and mechanistic exploration of an adult neurogenesis-promoting small
molecule. FASEB J. 2012 Aug;26(8):3148-62. doi: 10.1096/fj.11-201426. Epub 2012
Apr 27. PubMed PMID: 22542682; PubMed Central PMCID: PMC3405259.
