WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407155
Description: AZ191 is a novel, potent and selective DYRK1B inhibitor. AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288). AZ191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene. AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.
MedKoo Cat#: 407155
Chemical Formula: C24H27N7O
Exact Mass: 429.22771
Molecular Weight: 429.53
Elemental Analysis: C, 67.11; H, 6.34; N, 22.83; O, 3.72
AZ191 purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: AZ191; AZ-191; AZ 191.
IUPAC/Chemical Name: N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
InChi Key: ZYVXTMKTGDARKR-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
SMILES Code: CN1C=C(C2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2)C5=C1C=NC=C5
The following data is based on the product molecular weight 429.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA. A
novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β
to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem J. 2014 Jan
1;457(1):43-56. doi: 10.1042/BJ20130461. PubMed PMID: 24134204.