AZ191
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MedKoo CAT#: 407155

CAS#: 1594092-37-1

Description: AZ191 is a novel, potent and selective DYRK1B inhibitor. AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288). AZ191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene. AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.


Chemical Structure

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AZ191
CAS# 1594092-37-1

Theoretical Analysis

MedKoo Cat#: 407155
Name: AZ191
CAS#: 1594092-37-1
Chemical Formula: C24H27N7O
Exact Mass: 429.22771
Molecular Weight: 429.53
Elemental Analysis: C, 67.11; H, 6.34; N, 22.83; O, 3.72

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same Day
25.0mg USD 150.0 Same Day
50.0mg USD 250.0 Same Day
100.0mg USD 450.0 Same Day
200.0mg USD 850.0 Same Day
500.0mg USD 1850.0 Same Day
1.0g USD 2950.0 Same Day
2.0g USD 4650.0 2 Weeks
5.0g USD 7950.0 2 Weeks
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Synonym: AZ191; AZ-191; AZ 191.

IUPAC/Chemical Name: N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine

InChi Key: ZYVXTMKTGDARKR-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

SMILES Code: CN1C=C(C2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2)C5=C1C=NC=C5

Appearance: Brown solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 429.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA. A
novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β
to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem J. 2014 Jan
1;457(1):43-56. doi: 10.1042/BJ20130461. PubMed PMID: 24134204.

AZ191

10.0mg / USD 90.0