WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522391

CAS#: 188011-69-0

Description: Bikinin is a GSK-3 inhibitor. Bikinin directly binds the GSK3 BIN2 and acts as an ATP competitor. Bikinin inhibits the activity of six other Arabidopsis GSK3s. Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals and plants. Plant GSK-3/Shaggy-like kinases are key players in brassinosteroid (BR) signalling which impact on plant development and participate in response to wounding, pathogens and salt stress.

Chemical Structure

CAS# 188011-69-0

Theoretical Analysis

MedKoo Cat#: 522391
Name: Bikinin
CAS#: 188011-69-0
Chemical Formula: C9H9BrN2O3
Exact Mass: 271.97965
Molecular Weight: 273.09
Elemental Analysis: C, 39.58; H, 3.32; Br, 29.26; N, 10.26; O, 17.58

Price and Availability

Size Price Availability Quantity
100.0mg USD 550.0 2 weeks
200.0mg USD 750.0 2 weeks
500.0mg USD 1250.0 2 weeks
1.0g USD 1950.0 2 weeks
2.0g USD 2950.0 2 weeks
5.0g USD 4850.0 2 weeks
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Synonym: Bikinin

IUPAC/Chemical Name: 4-((5-bromopyridin-2-yl)amino)-4-oxobutanoic acid


InChi Code: InChI=1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 273.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mills-Lujan K, Andrews DL, Chou CW, Deom CM. The roles of phosphorylation and SHAGGY-like protein kinases in geminivirus C4 protein induced hyperplasia. PLoS One. 2015 Mar 27;10(3):e0122356. doi: 10.1371/journal.pone.0122356. eCollection 2015. PubMed PMID: 25815729; PubMed Central PMCID: PMC4376871.

2: Kondo Y, Fujita T, Sugiyama M, Fukuda H. A novel system for xylem cell differentiation in Arabidopsis thaliana. Mol Plant. 2015 Apr;8(4):612-21. doi: 10.1016/j.molp.2014.10.008. Epub 2014 Dec 13. PubMed PMID: 25624147.

3: Chung Y, Kwon SI, Choe S. Antagonistic regulation of Arabidopsis growth by brassinosteroids and abiotic stresses. Mol Cells. 2014 Nov;37(11):795-803. doi: 10.14348/molcells.2014.0127. Epub 2014 Nov 5. PubMed PMID: 25377253; PubMed Central PMCID: PMC4255099.

4: Kondo Y, Fujita T, Sugiyama M, Fukuda H. A novel system for xylem cell differentiation in Arabidopsis thaliana. Mol Plant. 2014 Oct 25. pii: ssu122. [Epub ahead of print] PubMed PMID: 25344955.

5: Rozhon W, Wang W, Berthiller F, Mayerhofer J, Chen T, Petutschnig E, Sieberer T, Poppenberger B, Jonak C. Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta. BMC Plant Biol. 2014 Jun 19;14:172. doi: 10.1186/1471-2229-14-172. PubMed PMID: 24947596; PubMed Central PMCID: PMC4078015.

6: Cai Z, Liu J, Wang H, Yang C, Chen Y, Li Y, Pan S, Dong R, Tang G, Barajas-Lopez Jde D, Fujii H, Wang X. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6. doi: 10.1073/pnas.1316717111. Epub 2014 Jun 13. PubMed PMID: 24928519; PubMed Central PMCID: PMC4084465.

7: De Rybel B, Audenaert D, Vert G, Rozhon W, Mayerhofer J, Peelman F, Coutuer S, Denayer T, Jansen L, Nguyen L, Vanhoutte I, Beemster GT, Vleminckx K, Jonak C, Chory J, Inzé D, Russinova E, Beeckman T. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604. doi: 10.1016/j.chembiol.2009.04.008. PubMed PMID: 19549598.


100.0mg / USD 550.0