WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407150
Description: BML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. ML-277 has IC50 = 15 nM; Ki = 37 nM. ML-277 shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively).
MedKoo Cat#: 407150
Chemical Formula: C20H14ClN3O2
Exact Mass: 363.07745
Molecular Weight: 363.8
Elemental Analysis: C, 66.03; H, 3.88; Cl, 9.74; N, 11.55; O, 8.80
BML-277 (Chk2 Inhibitor II), purity > 98%, is in stock.
Synonym: BML-277; BML 277; BML277; Chk2 Inhibitor II.
IUPAC/Chemical Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
InChi Key: UXGJAOIJSROTTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
SMILES Code: O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N
The following data is based on the product molecular weight 363.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|