J147
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MedKoo CAT#: 522384

CAS#: 1146963-51-0

Description: J147 is a potent neuroprotective and neurotrophic compound. J147 protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). J147. J147 reverses cognitive impairment in aged Alzheimer's disease mice. J147 is an exciting new compound that is extremely potent, safe in animal studies and orally active. J147 is a potential AD therapeutic due to its ability to provide immediate cognition benefits, and it also has the potential to halt and perhaps reverse disease progression in symptomatic animals as demonstrated in these studies.


Chemical Structure

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J147
CAS# 1146963-51-0

Theoretical Analysis

MedKoo Cat#: 522384
Name: J147
CAS#: 1146963-51-0
Chemical Formula: C18H17F3N2O2
Exact Mass: 350.12421
Molecular Weight: 350.34
Elemental Analysis: C, 61.71; H, 4.89; F, 16.27; N, 8.00; O, 9.13

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same day
25.0mg USD 150.0 Same day
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1450.0 Same day
1.0g USD 2250.0 Same day
2.0g USD 3850.0 Same day
5.0g USD 6850.0 2 Weeks
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Synonym: J147; J 147; J-147.

IUPAC/Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

InChi Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N

InChi Code: InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+

SMILES Code: O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F

Appearance: Light yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 350.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kim K, Park KS, Kim MK, Choo H, Chong Y. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Aug 25. [Epub ahead of print] PubMed PMID: 26303522.

2: Chen HY, Xu DP, Tan GL, Cai W, Zhang GX, Cui W, Wang JZ, Long C, Sun YW, Yu P, Tsim KW, Zhang ZJ, Han YF, Wang YQ. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 Aug;56(4):977-87. doi: 10.1007/s12031-015-0566-x. Epub 2015 May 17. PubMed PMID: 25982925.

3: Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. doi: 10.1186/alzrt179. eCollection 2013. PubMed PMID: 23673233; PubMed Central PMCID: PMC3706879.

4: Chiruta C, Zhao Y, Tang F, Wang T, Schubert D. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. doi: 10.1016/j.bmc.2013.03.020. Epub 2013 Mar 24. PubMed PMID: 23582448.

5: Wang M, Gao M, Zheng QH. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23(2):524-7. doi: 10.1016/j.bmcl.2012.11.031. Epub 2012 Nov 22. PubMed PMID: 23237833.

6: Magro M, van Geuns RJ. TheTryton side branch stent. EuroIntervention. 2010 Dec;6 Suppl J:J147-50. doi: 10.4244/EIJV6SUPJA25. PubMed PMID: 21930481.

7: Ishii R, Horie M. [Principles of PCR technologies]. Shokuhin Eiseigaku Zasshi. 2001 Apr;42(2):J147-51. Japanese. PubMed PMID: 11486392.

J147

10.0mg / USD 90.0