WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407149
Description: TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.
MedKoo Cat#: 407149
Name: TCS JNK 5a (JNK Inhibitor IX)
Chemical Formula: C20H16N2OS
Exact Mass: 332.09833
Molecular Weight: 332.42
Elemental Analysis: C, 72.26; H, 4.85; N, 8.43; O, 4.81; S, 9.64
TCS JNK 5a purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671, SC 202671, SC202671
IUPAC/Chemical Name: N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide
InChi Key: WQGDQGAFSDMBLA-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
SMILES Code: O=C(C1=CC=CC2=CC=CC=C21)NC(S3)=C(C#N)C4=C3CCCC4
The following data is based on the product molecular weight 332.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Jang WY, Lee JY, Lee ST, Jun do Y, Kim YH. Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells. Biochem Biophys Res Commun. 2014 Sep 26;452(3):845-51. doi: 10.1016/j.bbrc.2014.09.015. Epub 2014 Sep 16. PubMed PMID: 25218503.