APY0201
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MedKoo CAT#: 522383

CAS#: 1232221-74-7

Description: APY0201 is a potent and selective IL-12/23 inhibitor. APY0201 demonstrates ameliorated inflammation in an experimental model of colitis. Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 190 Same Day
25mg USD 350 Same Day
50mg USD 550 Same Day
100mg USD 850 Same Day
200mg USD 1450 Same Day
500mg USD 2450 Same Day
1g USD 2950 2 Weeks
2g USD 4950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

APY0201, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522383
Name: APY0201
CAS#: 1232221-74-7
Chemical Formula: C23H23N7O
Exact Mass: 413.19641
Molecular Weight: 413.48
Elemental Analysis: C, 66.81; H, 5.61; N, 23.71; O, 3.87


Synonym: APY0201; APY-0201; APY 0201.

IUPAC/Chemical Name: (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

InChi Key: RFZQYGBLRIKROZ-PCLIKHOPSA-N

InChi Code: InChI=1S/C23H23N7O/c1-17-3-2-4-18(13-17)16-25-27-21-15-23(29-9-11-31-12-10-29)30-22(26-21)14-20(28-30)19-5-7-24-8-6-19/h2-8,13-16H,9-12H2,1H3,(H,26,27)/b25-16+

SMILES Code: CC1=CC(/C=N/NC2=NC3=CC(C4=CC=NC=C4)=NN3C(N5CCOCC5)=C2)=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R,
Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T,
Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou
A, Yamamoto T. Structure-activity relationship study, target identification, and
pharmacological characterization of a small molecular IL-12/23 inhibitor,
APY0201. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9. doi:
10.1016/j.bmc.2014.03.036. Epub 2014 Apr 13. PubMed PMID: 24767819.