WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522383
CAS#: 1232221-74-7
Description: APY0201 is a potent and selective IL-12/23 inhibitor. APY0201 demonstrates ameliorated inflammation in an experimental model of colitis. Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis.
MedKoo Cat#: 522383
Name: APY0201
CAS#: 1232221-74-7
Chemical Formula: C23H23N7O
Exact Mass: 413.19641
Molecular Weight: 413.48
Elemental Analysis: C, 66.81; H, 5.61; N, 23.71; O, 3.87
Synonym: APY0201; APY-0201; APY 0201.
IUPAC/Chemical Name: (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
InChi Key: RFZQYGBLRIKROZ-PCLIKHOPSA-N
InChi Code: InChI=1S/C23H23N7O/c1-17-3-2-4-18(13-17)16-25-27-21-15-23(29-9-11-31-12-10-29)30-22(26-21)14-20(28-30)19-5-7-24-8-6-19/h2-8,13-16H,9-12H2,1H3,(H,26,27)/b25-16+
SMILES Code: CC1=CC(/C=N/NC2=NC3=CC(C4=CC=NC=C4)=NN3C(N5CCOCC5)=C2)=CC=C1
1: Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R,
Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T,
Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou
A, Yamamoto T. Structure-activity relationship study, target identification, and
pharmacological characterization of a small molecular IL-12/23 inhibitor,
APY0201. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9. doi:
10.1016/j.bmc.2014.03.036. Epub 2014 Apr 13. PubMed PMID: 24767819.
