CZC-54252
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407148

CAS#: 1191911-27-9

Description: CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target.


Chemical Structure

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CZC-54252
CAS# 1191911-27-9

Theoretical Analysis

MedKoo Cat#: 407148
Name: CZC-54252
CAS#: 1191911-27-9
Chemical Formula: C22H25ClN6O4S
Exact Mass: 504.13465
Molecular Weight: 504.99
Elemental Analysis: C, 52.33; H, 4.99; Cl, 7.02; N, 16.64; O, 12.67; S, 6.35

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2950 2 Weeks
2g USD 4250 2 Weeks
5g USD 7650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

CZC-54252, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: CZC-54252; CZC 54252; CZC54252.

IUPAC/Chemical Name: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide

InChi Key: CLGWUCNXOBLWFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)

SMILES Code: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 504.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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