WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407143

CAS#: 1104546-89-5

Description: BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). BYK204165 was found to be 100-fold more selective for PARP-1. BYK204165 might be novel and valuable tool for investigating PARP-1-mediated effects.

Chemical Structure

CAS# 1104546-89-5

Theoretical Analysis

MedKoo Cat#: 407143
Name: BYK204165
CAS#: 1104546-89-5
Chemical Formula: C15H12N2O2
Exact Mass: 252.08988
Molecular Weight: 252.27
Elemental Analysis: C, 71.42; H, 4.79; N, 11.10; O, 12.68

Price and Availability

Size Price Availability Quantity
5.0mg USD 255.0 2 Weeks
10.0mg USD 415.0 2 Weeks
25.0mg USD 715.0 2 Weeks
50.0mg USD 1045.0 2 Weeks
100.0mg USD 1565.0 2 Weeks
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Synonym: BYK204165; BYK-204165; BYK 204165; RT-017290; RT017290; RT 017290.

IUPAC/Chemical Name: (4Z)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione


InChi Code: InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-

SMILES Code: O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Eltze T, Boer R, Wagner T, Weinbrenner S, McDonald MC, Thiemermann C, Bürkle A, Klein T. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74(6):1587-98. doi: 10.1124/mol.108.048751. Epub 2008 Sep 22. PubMed PMID: 18809672.