WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407136
Description: PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.
MedKoo Cat#: 407136
Chemical Formula: C22H22N6O5
Exact Mass: 450.16517
Molecular Weight: 450.46
Elemental Analysis: C, 58.66; H, 4.92; N, 18.66; O, 17.76
PH11 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: PH11; PH-11; PH 11.
IUPAC/Chemical Name: methyl 2-((4-((3,4,5-trimethoxyphenyl)amino)imidazo[1,2-a][1,3,5]triazin-2-yl)amino)benzoate
InChi Key: HOGIPROMEUJZIJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H22N6O5/c1-30-16-11-13(12-17(31-2)18(16)32-3)24-22-27-20(26-21-23-9-10-28(21)22)25-15-8-6-5-7-14(15)19(29)33-4/h5-12H,1-4H3,(H2,23,24,25,26,27)
SMILES Code: O=C(OC)C1=CC=CC=C1NC2=NC3=NC=CN3C(NC4=CC(OC)=C(OC)C(OC)=C4)=N2
The following data is based on the product molecular weight 450.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dao P, Smith N, Scott-Algara D, Garbay C, Herbeuval JP, Chen H. Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11. Cancer Lett. 2015 Apr 28;360(1):48-59. doi: 10.1016/j.canlet.2015.02.016. Epub 2015 Feb 12. PubMed PMID: 25684663.