NZ-28

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MedKoo CAT#: 407131

CAS#: 75041-32-6

Description: NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.


Price and Availability

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Pricing updated 2020-09-20. Prices are subject to change without notice.

NZ-28 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407131
Name: NZ-28
CAS#: 75041-32-6
Chemical Formula: C27H34N2O2
Exact Mass: 418.26203
Molecular Weight: 418.58
Elemental Analysis: C, 77.48; H, 8.19; N, 6.69; O, 7.64


Synonym: NZ-28; NZ28; NZ 28; NSC 134754; NSC 134754; NSC134754.

IUPAC/Chemical Name: (S)-3-ethyl-9,10-dimethoxy-2-(((R)-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline

InChi Key: HDIJLRXRAJUXQB-RPBOFIJWSA-N

InChi Code: InChI=1S/C27H34N2O2/c1-4-18-17-29-12-10-20-15-26(30-2)27(31-3)16-23(20)25(29)14-21(18)13-24-22-8-6-5-7-19(22)9-11-28-24/h5-8,15-16,24-25,28H,4,9-14,17H2,1-3H3/t24-,25+/m1/s1

SMILES Code: COC1=C(OC)C=C(CCN2CC(CC)=C(C[C@H]3NCCC4=C3C=CC=C4)C[C@]25[H])C5=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015 May;64(5):599-608. doi: 10.1007/s00262-015-1665-9. Epub 2015 Feb 18. PubMed PMID: 25854583; PubMed Central PMCID: PMC4412431.

2: Schilling D, Kühnel A, Konrad S, Tetzlaff F, Bayer C, Yaglom J, Multhoff G. Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Lett. 2015 May 1;360(2):294-301. doi: 10.1016/j.canlet.2015.02.033. Epub 2015 Feb 23. PubMed PMID: 25721082.

3: Kudriavtsev VA, Makarova IuM, Kabakav AE. [Thermosensitization of tumor cells with inhibitors of chaperone activity and expression]. Biomed Khim. 2012 Nov-Dec;58(6):662-72. Russian. PubMed PMID: 23350198.

4: Meng L, Gabai VL, Sherman MY. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene. 2010 Sep 16;29(37):5204-13. doi: 10.1038/onc.2010.277. Epub 2010 Jul 12. PubMed PMID: 20622894; PubMed Central PMCID: PMC2940982.

5: Zaarur N, Gabai VL, Porco JA Jr, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1;66(3):1783-91. PubMed PMID: 16452239.

6: Seppo A, Moreland M, Schweingruber H, Tiemeyer M. Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryo. Eur J Biochem. 2000 Jun;267(12):3549-58. PubMed PMID: 10848971.