LCRF-0004

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407124

CAS#: 1229611-73-7

Description: LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.


Chemical Structure

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LCRF-0004
CAS# 1229611-73-7

Theoretical Analysis

MedKoo Cat#: 407124
Name: LCRF-0004
CAS#: 1229611-73-7
Chemical Formula: C28H18F4N6O2S
Exact Mass: 578.11481
Molecular Weight: 578.55
Elemental Analysis: C, 58.13; H, 3.14; F, 13.14; N, 14.53; O, 5.53; S, 5.54

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-07. Prices are subject to change without notice.

LCRF-0004 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: LCRF-0004; LCRF 0004; LCRF0004.

IUPAC/Chemical Name: N-(3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

InChi Key: DVRMYRDLCLUXQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)

SMILES Code: O=C(C1=C(C(F)(F)F)N(C2=CC=CC=C2)N=C1)NC3=CC=C(OC4=C5C(C=C(C6=CN(C)C=N6)S5)=NC=C4)C(F)=C3

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 578.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Raeppel F, Raeppel SL, Therrien E. Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004. Bioorg Med Chem Lett. 2015 Jul 29. pii: S0960-894X(15)00784-2. doi: 10.1016/j.bmcl.2015.07.080. [Epub ahead of print] PubMed PMID: 26243370.

2: Raeppel SL, Therrien E, Raeppel F. Design and synthesis of constrained analogs of LCRF-0004 as potent RON tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3706-10. doi: 10.1016/j.bmcl.2015.06.034. Epub 2015 Jun 15. PubMed PMID: 26112445.

3: Raeppel SL, Raeppel F, Therrien E. Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2527-31. doi: 10.1016/j.bmcl.2015.04.056. Epub 2015 Apr 23. PubMed PMID: 25953155.

LCRF-0004

10mg / Not available