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MedKoo CAT#: 407121
CAS#: 438190-29-5
Description: SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.
MedKoo Cat#: 407121
Name: SMI-4a
CAS#: 438190-29-5
Chemical Formula: C11H6F3NO2S
Exact Mass: 273.00713
Molecular Weight: 273.23
Elemental Analysis: C, 48.36; H, 2.21; F, 20.86; N, 5.13; O, 11.71; S, 11.73
Synonym: SMI-4a; SMI4a; SMI 4a; TCS PIM-1 4a.
IUPAC/Chemical Name: 5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione
InChi Key: NGJLOFCOEOHFKQ-VMPITWQZSA-N
InChi Code: InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5+
SMILES Code: O=C(NC/1=O)SC1=C\C2=CC=CC(C(F)(F)F)=C2
1: Cervantes-Gomez F, Lavergne B, Keating MJ, Wierda WG, Gandhi V. Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cells. Leuk Lymphoma. 2015 Jun 19:1-23. [Epub ahead of print] PubMed PMID: 26088877.
2: Yang J, Wang J, Chen K, Guo G, Xi R, Rothman PB, Whitten D, Zhang L, Huang S, Chen JL. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. doi: 10.1158/0008-5472.CAN-12-4277. Epub 2013 Jun 7. PubMed PMID: 23749639.
3: Beharry Z, Mahajan S, Zemskova M, Lin YW, Tholanikunnel BG, Xia Z, Smith CD, Kraft AS. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):528-33. doi: 10.1073/pnas.1013214108. Epub 2010 Dec 27. PubMed PMID: 21187426; PubMed Central PMCID: PMC3021022.
4: Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, Kraft AS. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. doi: 10.1182/blood-2009-07-233445. Epub 2009 Nov 23. PubMed PMID: 19965690; PubMed Central PMCID: PMC2941996.